Goat CTDSP1/SCP1 Polyclonal Antibody | anti-CTDSP1/SCP1 antibody

Anti-CTDSP1/SCP1 Antibody (aa82-92)

Cat. Num. AAA2400868

• Gene Names: CTDSP1; NIF3; SCP1; NLIIF; NLI-IF
• Reactivity: Human; Predicted: Rabbit, Mouse, Guinea pig, Bovine, Hamster
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: CTDSP1/SCP1; Polyclonal Antibody; Anti-CTDSP1/SCP1 Antibody (aa82-92); Goat Polyclonal to Human CTDSP1/SCP1; CTDSP1; NIF3; NLIIF; NLI-IF; SCP1; NLI-interacting factor 3; Small CTD phosphatase 1; anti-CTDSP1/SCP1 antibody

• Host: Goat
• Reactivity: Human; Predicted: Rabbit, Mouse, Guinea pig, Bovine, Hamster
• Clonality: Polyclonal
• Specificity: Human CTDSP1. This antibody is expected to recognise both reported isoforms (NP_067021 and NP_872580)
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Sequence Length: 261

• Applicable Applications for anti-CTDSP1/SCP1 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:16000; IHC-P: 5 ug/ml; WB: 0.1-0.3 ug/ml
• Immunogen: Synthetic peptide EAKAQDSDKIC from an internal region of human CTDSP1 (NP_067021.1; NP_872580.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Galago, Marmoset, Mouse, Bovine, Hamster, Elephant, Rabbit, Guinea pig (100%); Monkey, Rat, Dog, Panda (91%); Opossum (82%).
• Conjugation: Unconjugated
• Epitope: aa82-92
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-CTDSP1/SCP1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CTDSP1/SCP1 antibody

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largestRNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase IItranscription, possibly by controlling the transition frominitiation/capping to processive transcript elongation. Recruited byREST to neuronal genes that contain RE-1 elements, leading to neuronalgene silencing in non-neuronal cells.

NCBI and Uniprot Product Information

• NCBI GI #: 10864009
• NCBI GeneID: 58190
• NCBI Accession #: NP_067021.1
• NCBI GenBank Nucleotide #: NM_021198.2
• UniProt Accession #: Q9GZU7; Q7Z5Q3; Q7Z5Q4; C9IYG0
• Molecular Weight: 29,128 Da
• NCBI Official Full Name: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
• NCBI Official Synonym Full Names: CTD small phosphatase 1
• NCBI Official Symbol: CTDSP1
• NCBI Official Synonym Symbols: NIF3; SCP1; NLIIF; NLI-IF
• NCBI Protein Information: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
• UniProt Protein Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
• UniProt Gene Name: CTDSP1
• UniProt Synonym Gene Names: NIF3; NLIIF; SCP1; NLI-IF; NLI-interacting factor 3; SCP1; Small CTD phosphatase 1

NCBI Description

This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.