Rabbit anti-Human, Mouse CTC1 Polyclonal Antibody | anti-CTC1 antibody

CTC1 Antibody

Cat. Num. AAA9630790

• Gene Names: CTC1; CRMCC; AAF132; AAF-132; C17orf68; tmp494178
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: CTC1; Polyclonal Antibody; CTC1 Antibody; C17orf68; Conserved telomere maintenance component 1; CST complex subunit CTC1; CTC1_HUMAN; HBV DNAPTP1-transactivated protein B; anti-CTC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: CTC1 Antibody detects endogenous levels of CTC1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CTC1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human CTC1.
• Conjugation: Unconjugated
• Similarity: Belongs to the CTC1 family.
• Subunit Structure: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with STN1. Interacts with ACD and POT1.
• Function: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Involved in telomere maintenance. Involved in genome stability. May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity).
• Note: A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-CTC1 antibody

Nucleus; Chromosome; Telomere; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 292495002
• NCBI GeneID: 80169
• UniProt Accession #: Q2NKJ3; Q1PCD1; Q2TBE3; Q8N3S6; Q9H6L0; B3KR66; C9JEX5
• Molecular Weight: 114,142 Da
• NCBI Official Full Name: CST complex subunit CTC1
• NCBI Official Synonym Full Names: CTS telomere maintenance complex component 1
• NCBI Official Symbol: CTC1
• NCBI Official Synonym Symbols: CRMCC; AAF132; AAF-132; C17orf68; tmp494178
• NCBI Protein Information: CST complex subunit CTC1
• UniProt Protein Name: CST complex subunit CTC1
• Protein Family: CST complex
• UniProt Gene Name: CTC1
• UniProt Synonym Gene Names: C17orf68
• UniProt Entry Name: CTC1_HUMAN

NCBI Description

This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

Uniprot Description

CTC1: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Defects in CTC1 are the cause of cerebroretinal microangiopathy with calcifications and cysts (CRMCC). An autosomal recessive pleiomorphic disorder characterized primarily by intracranial calcifications, leukodystrophy, and brain cysts. Affected individuals manifest a phenotype consistent with Coats plus syndrome or Labrune syndrome. Coats plus syndrome patients have retinal telangiectasia and exudates as well as extraneurologic manifestations, including osteopenia with poor bone healing and a high risk of gastrointestinal bleeding and portal hypertension caused by vasculature ectasias in the stomach, small intestine, and liver. Some individuals with Coats syndrome also have hair, skin, and nail changes, as well as anemia. Patients with Labrune syndrome do not have extraneurologic manifestations. Belongs to the CTC1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA replication; DNA-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nuclear chromosome, telomeric region; nucleus

Molecular Function: protein binding; single-stranded DNA binding; telomeric DNA binding

Biological Process: bone marrow development; multicellular organism growth; negative regulation of telomerase activity; positive regulation of DNA replication; positive regulation of fibroblast proliferation; regulation of G2/M transition of mitotic cell cycle; response to DNA damage stimulus; spleen development; telomere maintenance; thymus development

Disease: Cerebroretinal Microangiopathy With Calcifications And Cysts