Rabbit anti-Human CST6 Polyclonal Antibody | anti-CST6 antibody

CST6 Antibody

Cat. Num. AAA9406778

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: CST6; Polyclonal Antibody; CST6 Antibody; cystatin 6; cystatin M; cystatin M/E; anti-CST6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CST6 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.3 mg/ml (varies by lot)
• Sequence Length: 149

• Applicable Applications for anti-CST6 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human cystatin E/M
• Target Name: CST6
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using at dilution 1/30.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/30.)

Related Product Information for anti-CST6 antibody

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Product Categories/Family for anti-CST6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4503113
• NCBI GeneID: 1474
• NCBI Accession #: NP_001314.1
• NCBI GenBank Nucleotide #: NM_001323.3
• UniProt Accession #: Q15828; Q540N7
• Molecular Weight: 16,511 Da
• NCBI Official Full Name: cystatin-M
• NCBI Official Synonym Full Names: cystatin E/M
• NCBI Official Symbol: CST6
• NCBI Protein Information: cystatin-M
• UniProt Protein Name: Cystatin-M
• Protein Family: Cystatin
• UniProt Gene Name: CST6
• UniProt Entry Name: CYTM_HUMAN

NCBI Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

Uniprot Description

CST6: Shows moderate inhibition of cathepsin B but is not active against cathepsin C. Belongs to the cystatin family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cornified envelope

Molecular Function: cysteine protease inhibitor activity

Biological Process: epidermis development; anatomical structure morphogenesis