Western Blot (WB)
(Mouse Csnk1e Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Csnk1e antibody detected the Csnk1e protein (arrow).)
Rabbit Csnk1e Polyclonal Antibody | anti-Csnk1e antibody
Mouse Csnk1e Antibody (C-term)
Western Blot (WB)
(Mouse Csnk1e Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Csnk1e antibody detected the Csnk1e protein (arrow).)
Western Blot (WB)
(Mouse Csnk1e Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Csnk1e antibody detected the Csnk1e protein (arrow).)
Immunohistochemistry (IHC)
(Mouse Csnk1e Antibody (C-term) (MBS9207626)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse live tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Csnk1e Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Mouse Csnk1e Antibody (C-term) (MBS9207626)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse live tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Csnk1e Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Sugiyama, Y., et al. Biochem. J. 427(3):489-497(2010)
Etchegaray, J.P., et al. PLoS ONE 5 (4), E10303 (2010) :
Lee, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21359-21364(2009)
Isojima, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15744-15749(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Uniprot Description
CK1E: an ubiquitous protein kinase of the CK1 family. Together with Dvl-1 and Frat-1 activate the Wnt signaling pathway. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. May play a role in cell cycle progression. Two splice variant isoforms have been described. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CK1-D and/or CK1-E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with SOCS3. Mutations in hamster and Drosophila orthologs have circadian rhythm phenotypes, and the circadian gene period (per) is a substrate in both human and fly. A coding SNP variant in human, which increases CK1 activity, is negatively associated with circadian disorder. LOF mutations and LOH seen in mammary ductal carcinoma.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family
Cellular Component: cytoplasm; ribonucleoprotein complex; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: circadian rhythm; regulation of cell shape; peptidyl-serine phosphorylation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; rhythmic process; endocytosis; circadian regulation of gene expression; regulation of circadian rhythm; protein amino acid phosphorylation; phosphorylation
Research Articles on Csnk1e
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Product Notes
The Csnk1e csnk1e (Catalog #AAA9207626) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 283-310. The Mouse Csnk1e Antibody (C-term) reacts with Mouse (Predicted Reactivity: Human) and may cross-react with other species as described in the data sheet. AAA Biotech's Csnk1e can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the Csnk1e csnk1e for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Csnk1e, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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