Western Blot (WB)
(CRYGS Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the CRYGS antibody detected the CRYGS protein (arrow).)
Rabbit anti-Human, mouse CRYGS Polyclonal Antibody | anti-CRYGS antibody
CRYGS Antibody (C-term)
Western Blot (WB)
(CRYGS Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the CRYGS antibody detected the CRYGS protein (arrow).)
Western Blot (WB)
(CRYGS Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the CRYGS antibody detected the CRYGS protein (arrow).)
taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains
the transparency and refractive index of the lens. Since lens
central fiber cells lose their nuclei during development, these
crystallins are made and then retained throughout life, making them
extremely stable proteins. Mammalian lens crystallins are divided
into alpha, beta, and gamma families; beta and gamma crystallins
are also considered as a superfamily. Alpha and beta families are
further divided into acidic and basic groups. Seven protein regions
exist in crystallins: four homologous motifs, a connecting peptide,
and N- and C-terminal extensions. Gamma-crystallins are a
homogeneous group of highly symmetrical, monomeric proteins
typically lacking connecting peptides and terminal extensions. They
are differentially regulated after early development. This gene
encodes a protein initially considered to be a beta-crystallin but
the encoded protein is monomeric and has greater sequence
similarity to other gamma-crystallins. This gene encodes the most
significant gamma-crystallin in adult eye lens tissue. Whether due
to aging or mutations in specific genes, gamma-crystallins have
been involved in cataract formation.
Ma, Z., et al. Biochemistry 48(30):7334-7341(2009)
Chen, J., et al. Biochemistry 48(17):3708-3716(2009)
Vanita, V., et al. Mol. Vis. 15, 476-481 (2009) :
Mills, I.A., et al. Protein Sci. 16(11):2427-2444(2007)
NCBI and Uniprot Product Information
NCBI Description
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]
Uniprot Description
CRYGS: Crystallins are the dominant structural components of the vertebrate eye lens. Belongs to the beta/gamma-crystallin family.
Chromosomal Location of Human Ortholog: 3q27.3
Molecular Function: structural constituent of eye lens
Biological Process: lens development in camera-type eye; morphogenesis of an epithelium
Disease: Cataract 20, Multiple Types
Research Articles on CRYGS
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Product Notes
The CRYGS crygs (Catalog #AAA9206229) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 133-162. The CRYGS Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CRYGS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CRYGS crygs for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRYGS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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