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Western Blot (WB) (Western blot analysis of CRHBP (arrow) using rabbit polyclonal CRHBP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRHBP gene.)

Rabbit anti-Human CRHBP Polyclonal Antibody | anti-CRHBP antibody

CRHBP Antibody (N-term)

Gene Names
CRHBP; CRFBP; CRF-BP
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CRHBP; Polyclonal Antibody; CRHBP Antibody (N-term); Corticotropin-releasing factor-binding protein; CRF-BP; CRF-binding protein; Corticotropin-releasing hormone-binding protein; CRH-BP; CRFBP; anti-CRHBP antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CRHBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human CRHBP.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
7-36
Sequence Length
322
Applicable Applications for anti-CRHBP antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of CRHBP (arrow) using rabbit polyclonal CRHBP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRHBP gene.)

Western Blot (WB) (Western blot analysis of CRHBP (arrow) using rabbit polyclonal CRHBP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRHBP gene.)
Related Product Information for anti-CRHBP antibody
Corticotropin-releasing hormone is a potent stimulator of
synthesis and secretion of preopiomelanocortin-derived peptides.
Although CRH concentrations in the human peripheral circulation are
normally low, they increase throughout pregnancy and fall rapidly
after parturition. Maternal plasma CRH probably originates from the
placenta. Human plasma contains a CRH-binding protein which
inactivates CRH and which may prevent inappropriate
pituitary-adrenal stimulation in pregnancy.
Product Categories/Family for anti-CRHBP antibody
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)
Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
36144
NCBI Official Full Name
corticotropin-releasing factor-binding protein
NCBI Official Synonym Full Names
corticotropin releasing hormone binding protein
NCBI Official Symbol
CRHBP
NCBI Official Synonym Symbols
CRFBP; CRF-BP
NCBI Protein Information
corticotropin-releasing factor-binding protein
UniProt Protein Name
Corticotropin-releasing factor-binding protein
UniProt Gene Name
CRHBP
UniProt Synonym Gene Names
CRFBP; CRF-BP; CRF-binding protein; CRH-BP
UniProt Entry Name
CRHBP_HUMAN

NCBI Description

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

Uniprot Description

CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: multivesicular body; Golgi apparatus; extracellular space; microtubule; endoplasmic reticulum; dendrite; perikaryon; intracellular; nerve terminal; nucleus; secretory granule

Molecular Function: protein binding; corticotropin-releasing hormone binding; peptide binding

Biological Process: negative regulation of adrenocorticotropic hormone secretion; synaptic transmission, dopaminergic; regulated secretory pathway; learning and/or memory; hormone-mediated signaling; cellular response to stress; regulation of adrenocorticotropin hormone secretion; hormone metabolic process; female pregnancy; behavioral response to ethanol; signal transduction; inflammatory response

Research Articles on CRHBP

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Product Notes

The CRHBP crhbp (Catalog #AAA9212171) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 7-36. The CRHBP Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CRHBP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CRHBP crhbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRHBP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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