Rabbit anti-Human CREB3L2 Polyclonal Antibody | anti-CREB3L2 antibody

CREB3L2, CT (CREB3L2, BBF2H7, Cyclic AMP-responsive element-binding protein 3-like protein 2, BBF2 human homolog on chromosome 7, Processed cyclic AMP-responsive element-binding protein 3-like protein 2) (APC)

Cat. Num. AAA6288638

• Gene Names: CREB3L2; BBF2H7
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CREB3L2; Polyclonal Antibody; CT (CREB3L2; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7; Processed cyclic AMP-responsive element-binding protein 3-like protein 2) (APC); Processed cyclic AMP-responsive element-binding protein 3-like protein 2; anti-CREB3L2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CREB3L2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CREB3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491~520 amino acids from the C-terminal region of human CREB3L2.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CREB3L2 Antibody (C-term) western blot analysis in human placenta and mouse lung tissue lysates (35ug/lane).This demonstrates the CREB3L2 antibody detected the CREB3L2 protein (arrow).)

Related Product Information for anti-CREB3L2 antibody

CREB3L2 is a member of the old astrocyte specifically induced substance (OASIS) DNA binding and basic leucine zipper dimerization (bZIP) family of transcription factors, which includes CREB3 (MIM 606443) and CREB4 (MIM 607138).

Product Categories/Family for anti-CREB3L2 antibody

Antibodies; Binding Proteins

References

Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009). Lui, W.O., et al. Cancer Res. 68(17):7156-7164(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 359339005
• NCBI GeneID: 64764
• NCBI Accession #: NP_001240704.1
• NCBI GenBank Nucleotide #: NM_001253775.1
• UniProt Accession #: Q70SY1; Q6P454; Q6ZMR6
• Molecular Weight: 57,415 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 2
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3-like 2
• NCBI Official Symbol: CREB3L2
• NCBI Official Synonym Symbols: BBF2H7
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 2; TCAG_1951439; FUS/BBF2H7 protein; B-ZIB transcription factor; basic transcription factor 2; BBF2 human homolog on chromosome 7; cAMP-responsive element-binding protein 3-like protein 2
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 2
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: CREB3L2
• UniProt Synonym Gene Names: BBF2H7; cAMP-responsive element-binding protein 3-like protein 2
• UniProt Entry Name: CR3L2_HUMAN

NCBI Description

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, integral; Oncoprotein

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Biological Process: ER to Golgi vesicle-mediated transport; transcription, DNA-dependent; unfolded protein response; cartilage development; positive regulation of transcription, DNA-dependent; chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter