Immunohistochemistry (IHC)
(Immunochemical staining of human CR1 in human tonsil with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human CR1/CD35 Polyclonal Antibody | anti-CR1 antibody
Anti-CR1/CD35 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
CR1/CD35; Polyclonal Antibody; Anti-CR1/CD35 Antibody; Rabbit Polyclonal; CR1 Antibody; Rabbit PAb; Antigen Affinity Purified; complement component 3b/4b receptor 1 (Knops blood group); Anti-C3BR Antibody; Anti-C4BR Antibody; Anti-CD35 Antibody; Anti-KN Antibody; Anti-RP11-57I17.1 Antibody; anti-CR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human CR1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-CR1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human CR1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human CR1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human CR1 in human tonsil with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human CR1 in human tonsil with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human CR1 in human spleen with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human CR1 in human spleen with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-CR1 antibody
Complement receptor type 1 (CR1) is a multi-modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor for complement-opsonins C3b and C4b and specifically interacts through pairs of CCP modules located in LHR A, B, and C. Human CR1 plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Lower CR1 expression has been associated with susceptibility to systemic lupus erythematosus (SLE). In contrast, subjects displaying lower CR1 expression are protected against severe manifestations of falciparum malaria. The CR1 gene was shown to be involved in Alzheimer's disease (AD).
References
Sandri TL, et al. (2018) Human complement receptor type 1 (cr1) protein levels and genetic variants in chronic chagas disease. Sci Rep 8 (1): 526.Panda AK, et al. (2016) Cr1 exon variants are associated with lowered cr1 expression and increased susceptibility to sle in a plasmodium falciparum endemic population. Lupus Sci Med 3 (1): e000145.Mahmoudi R, et al. (2018) Inherited and acquired decrease in complement receptor 1 (cr1) density on red blood cells associated with high levels of soluble cr1 in alzheimer's disease. Int J Mol Sci 19 (8): 2175.Jacquet M, et al. (2018) C1q and mannose-binding lectin interact with cr1 in the same region on ccp24-25 modules. Front Immunol 9 453.
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Product Notes
The CR1 (Catalog #AAA8108788) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CR1/CD35 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CR1/CD35 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the CR1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CR1/CD35, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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