Goat anti-Human CPT1A Polyclonal Antibody | anti-CPT1A antibody

CPT1A (Cpt1a, carnitine palmitoyltransferase 1A, liver, CPT1, CPT1-L, L-CPT1, C730027G07, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1, liver)

Cat. Num. AAA620426

• Gene Names: CPT1A; CPT1; CPT1-L; L-CPT1
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: CPT1A; Polyclonal Antibody; CPT1A (Cpt1a; carnitine palmitoyltransferase 1A; liver; CPT1; CPT1-L; L-CPT1; C730027G07; carnitine palmitoyltransferase 1; liver); Anti -CPT1A (Cpt1a; anti-CPT1A antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes mouse CPT1A. Species sequence homology: rat, porcine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-CPT1A antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:32000
• Immunogen: Synthetic peptide with sequence C-PETDSHRFGKHLRQ, from the C Terminus of murine CPT1A (NP_038523.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-CPT1A antibody

The CPT1A gene provides instructions for making a liver enzyme called carnitine palmitoyl transferase I. This enzyme assists in the transport of certain fats, called long-chain fatty acids, into the energy-producing centers in the cell (mitochondria). This process is necessary for these fats to be broken down for energy. Long-chain fatty acids must be joined to a naturally occurring substance called carnitine for entry into the mitochondria. Carnitine palmitoyl transferase I connects the long-chain fatty acids to carnitine to promote this transport process.

Product Categories/Family for anti-CPT1A antibody

Antibodies; Abs to Enzymes;  Transferase

NCBI and Uniprot Product Information

• NCBI GI #: 73623030
• NCBI GeneID: 1374
• NCBI Accession #: NP_001867.2
• NCBI GenBank Nucleotide #: NM_001876.3
• UniProt Accession #: P50416; Q8TCU0; Q9BWK0; Q8WZ48
• Molecular Weight: 88,368 Da
• NCBI Official Full Name: carnitine O-palmitoyltransferase 1, liver isoform isoform 1
• NCBI Official Synonym Full Names: carnitine palmitoyltransferase 1A (liver)
• NCBI Official Symbol: CPT1A
• NCBI Official Synonym Symbols: CPT1; CPT1-L; L-CPT1
• NCBI Protein Information: carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; OTTHUMP00000237196; OTTHUMP00000237197; OTTHUMP00000237552; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform
• UniProt Protein Name: Carnitine O-palmitoyltransferase 1, liver isoform
• Protein Family: Carnitine O-palmitoyltransferase
• UniProt Gene Name: CPT1A
• UniProt Synonym Gene Names: CPT1
• UniProt Entry Name: CPT1A_HUMAN

NCBI Description

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transferase; Membrane protein, integral; EC 2.3.1.21; Mitochondrial; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane

Molecular Function: identical protein binding; carnitine O-palmitoyltransferase activity

Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; carnitine shuttle; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; triacylglycerol metabolic process; fatty acid beta-oxidation; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Carnitine Palmitoyltransferase I Deficiency