Rabbit anti-Human COUP-TF II Polyclonal Antibody | anti-COUP-TFII antibody

COUP-TF II polyclonal antibody

Cat. Num. AAA3015839

• Gene Names: NR2F2; ARP1; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Synonyms: COUP-TF II; Polyclonal Antibody; COUP-TF II polyclonal antibody; COUP transcription factor 2; Apolipoprotein A-I regulatory protein 1; COUP transcription factor II; COUP-TF2; Nuclear receptor subfamily 2 group F member 2; ARP-1; NR2F2; ARP1; TFCOUP2; anti-COUP-TFII antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: COUP-TF II polyclonal antibody detects endogenous levels of COUP-TF II protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

• Applicable Applications for anti-COUP-TFII antibody: Western Blot (WB)
• Application Notes: WB: 1:1000~1:2000
• Immunogen: Synthetic peptide, corresponding to Human COUP-TF II.
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Related Product Information for anti-COUP-TFII antibody

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation. COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.

NCBI and Uniprot Product Information

• NCBI GI #: 223555949
• NCBI GeneID: 7026
• NCBI Accession #: NP_001138627.1
• NCBI GenBank Nucleotide #: NM_001145155.1
• UniProt Accession #: P24468; Q03754; Q3KQR7; B4DQJ2; B6ZGU1
• Molecular Weight: 45,571 Da
• NCBI Official Full Name: COUP transcription factor 2 isoform b
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2, group F, member 2
• NCBI Official Symbol: NR2F2
• NCBI Official Synonym Symbols: ARP1; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII
• NCBI Protein Information: COUP transcription factor 2; COUP transcription factor II; apolipoprotein AI regulatory protein 1; apolipoprotein A-I regulatory protein 1; ADP-ribosylation factor related protein 1; chicken ovalbumin upstream promoter transcription factor 2; chicken oval
• UniProt Protein Name: COUP transcription factor 2
• UniProt Gene Name: NR2F2
• UniProt Synonym Gene Names: ARP1; TFCOUP2; COUP-TF2; ARP-1; COUP-TF II
• UniProt Entry Name: COT2_HUMAN

NCBI Description

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; transcription factor activity

Biological Process: limb development; skeletal muscle development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; anterior/posterior pattern formation; regulation of transcription from RNA polymerase II promoter; fertilization; forebrain development; negative regulation of endothelial cell proliferation; blood vessel morphogenesis; steroid hormone mediated signaling; lipid metabolic process; negative regulation of transcription, DNA-dependent; radial pattern formation; maternal placenta development

Disease: Congenital Heart Defects, Multiple Types, 4