Western Blot (WB)
(staining (0.2ug/ml) of human lung lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Goat CORO1C Polyclonal Antibody | anti-CORO1C antibody
CORO1C (Coronin 3, Coronin-1C, Coronin-3, hCRNN4, CRNN4)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:64,000
Western Blot: 0.2-1ug/ml, observed in human lung and placenta lysates on ~55kD bands
Western Blot (WB)
(staining (0.2ug/ml) of human lung lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Western Blot (WB)
(staining (0.2ug/ml) of human lung lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Description
Function: May be involved in cytokinesis, motility, and signal transduction
By similarity. Ref.2Isoform 3: Involved in myogenic differentiation. Ref.2
Subunit structure: Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers. Ref.2 Ref.8
Subcellular location: Cell membrane. Cell projection › lamellipodium. Cytoplasm › cytoskeleton. Note: All isoforms localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform 3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Ref.8
Tissue specificity: Ubiquitous.
Domain: The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
Sequence similarities: Belongs to the WD repeat coronin family.Contains 5 WD repeats.
Sequence caution: The sequence CAB82406.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on CORO1C
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Product Notes
The CORO1C coro1c (Catalog #AAA647017) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The CORO1C (Coronin 3, Coronin-1C, Coronin-3, hCRNN4, CRNN4) reacts with Bovine, Human, Porcine and may cross-react with other species as described in the data sheet. AAA Biotech's CORO1C can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:64,000 Western Blot: 0.2-1ug/ml, observed in human lung and placenta lysates on ~55kD bands. Researchers should empirically determine the suitability of the CORO1C coro1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CORO1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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