Testing Data
(Figure: Immunodetection of human cornulin using MBS614490. Method: Staining performed on frozen sections of esophagus (A-B), foreskin (C-D) and scalp (D-E) using MBS614490 at 1:100 in PBS containing 12% BSA. Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle, in normal esophagus, the staining is localized in the upper spinous and granular layers with strong peripheral localization. Control sections (B,D,E) show no staining. Basal layer is indicated (solid red line) [see 1].)
Rabbit anti-Human Cornulin Polyclonal Antibody | anti-CRNN antibody
Cornulin
Purified by affinity chromatography.
Purified by affinity chromatography.
Dilution: Western Blot: 1:2000. Detects a band at ~70kD.
Immunohistochemistry (frozen): 1:100
Testing Data
(Figure: Immunodetection of human cornulin using MBS614490. Method: Staining performed on frozen sections of esophagus (A-B), foreskin (C-D) and scalp (D-E) using MBS614490 at 1:100 in PBS containing 12% BSA. Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle, in normal esophagus, the staining is localized in the upper spinous and granular layers with strong peripheral localization. Control sections (B,D,E) show no staining. Basal layer is indicated (solid red line) [see 1].)
Testing Data
(Figure: Immunodetection of human cornulin using MBS614490. Method: Staining performed on frozen sections of esophagus (A-B), foreskin (C-D) and scalp (D-E) using MBS614490 at 1:100 in PBS containing 12% BSA. Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle, in normal esophagus, the staining is localized in the upper spinous and granular layers with strong peripheral localization. Control sections (B,D,E) show no staining. Basal layer is indicated (solid red line) [see 1].)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq]
Uniprot Description
CRNN: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. Belongs to the S100-fused protein family.
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: membrane; cytoplasm
Molecular Function: calcium ion binding
Biological Process: cell-cell adhesion; response to heat
Research Articles on CRNN
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Product Notes
The CRNN crnn (Catalog #AAA614490) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cornulin reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cornulin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: 1:2000. Detects a band at ~70kD. Immunohistochemistry (frozen): 1:100. Researchers should empirically determine the suitability of the CRNN crnn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cornulin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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