Testing Data
Rabbit anti-Mouse Corin (IN) Polyclonal Antibody | anti-Corin antibody
Rabbit anti Corin (IN)
Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. [provided by RefSeq]
Uniprot Description
Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide. Ref.5
Enzyme regulation: Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine.
Subcellular location: Cell membrane; Single-pass type II membrane protein.
Tissue specificity: Highly expressed in heart. Expressed in heart myocytes. Ref.1
Post-translational modification: N-glycosylated; required for processing and activation
By similarity. Ref.7Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Ref.7A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.
Miscellaneous: Initially named CORIN due to its abundant expression in the heart (Ref.1).
Sequence similarities: Belongs to the peptidase S1 family.Contains 2 FZ (frizzled) domains.Contains 7 LDL-receptor class A domains.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.
Biophysicochemical propertiesKinetic parameters:KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl Ref.6KM=3.52 mM for pyroGlu-Pro-Arg-pNA.HClKM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HClKM=1.92 mM for Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HClKM=16 mM for pyroGlu-Gly-Arg-pNA.HCl
Research Articles on Corin
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Product Notes
The Corin corin (Catalog #AAA462039) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Corin (IN) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Corin (IN) can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot,. Suggested Dilution: Western Blot: 0.1-1 ug/ml ELISA: 0.01-0.1 ug/ml Immunoprecipitation: 2-5 ug/ml Immunohistochemistry: 0.5-2 ug/ml. Researchers should empirically determine the suitability of the Corin corin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Corin (IN), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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