Western Blot (WB)
(Western blot analysis: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody and (b) antibody pre-absorbed with cognate peptide.)
Rabbit COP9 signalosome Csn6 subunit Polyclonal Antibody | anti-COPS6 antibody
COP9 signalosome Csn6 subunit (human) polyclonal antibody
Does not cross-react with other signalosome subunits.
Does not cross-react with other signalosome subunits.
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Western Blot: The antibody has been characterized against both endogenousand purified signalosome preperations. Detects a band of -33.5kDa.
Western Blot (WB)
(Western blot analysis: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody and (b) antibody pre-absorbed with cognate peptide.)
Western Blot (WB)
(Western blot analysis: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody and (b) antibody pre-absorbed with cognate peptide.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Uniprot Description
COPS6: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. Belongs to the peptidase M67A family. CSN6 subfamily.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: cytoplasm; nucleoplasm; signalosome
Molecular Function: protein binding
Biological Process: cullin deneddylation; DNA repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; transcription-coupled nucleotide-excision repair; viral reproduction
Research Articles on COPS6
Similar Products
Product Notes
The COPS6 cops6 (Catalog #AAA565320) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COP9 signalosome Csn6 subunit (human) polyclonal antibody reacts with Human Does not cross-react with other signalosome subunits. and may cross-react with other species as described in the data sheet. AAA Biotech's COP9 signalosome Csn6 subunit can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Immunoblotting- The antibody has been characterised against both endogenous and purified signalsome preperations. The antibody does not cross-react with other signalsome subunits.An initial dilution of >1:1000 is recommended. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. Western Blot: The antibody has been characterized against both endogenousand purified signalosome preperations. Detects a band of -33.5kDa. Researchers should empirically determine the suitability of the COPS6 cops6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COP9 signalosome Csn6 subunit, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
