Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human placenta tissue using at dilution of 1:100.)
Rabbit anti-Human Complement C4-B Polyclonal Antibody | anti-C4B antibody
Complement C4-B Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human placenta tissue using at dilution of 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human placenta tissue using at dilution of 1:100.)
NCBI and Uniprot Product Information
Uniprot Description
C4B: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway. Defects in C4B are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Interindividual copy- number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE. Defects in C4B are the cause of complement component 4B deficiency (C4BD). A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus with or without associated glomerulonephritis.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: extracellular region; extracellular space; plasma membrane
Molecular Function: carbohydrate binding; complement binding; serine-type endopeptidase activity
Biological Process: complement activation; detection of molecule of bacterial origin; opsonization; regulation of complement activation
Disease: Complement Component 4b Deficiency
Similar Products
Product Notes
The C4B c4b (Catalog #AAA9415537) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Complement C4-B Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement C4-B can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the C4B c4b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement C4-B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
