Testing Data
(Sample(30 ug whole cell lysate)A: 293TB: A431 C: H1299D: HeLa S3 E: Hep G2 F: MOLT4 G: Raji 7.5% SDS PAGEPrimary antibody diluted at 1: 1000)
Rabbit anti-Human Complement C2 Polyclonal Antibody | anti-C2 antibody
Complement C2 antibody
Immunofluorescence: 1:100-1:200
Testing Data
(Sample(30 ug whole cell lysate)A: 293TB: A431 C: H1299D: HeLa S3 E: Hep G2 F: MOLT4 G: Raji 7.5% SDS PAGEPrimary antibody diluted at 1: 1000)
Testing Data
(Sample(30 ug whole cell lysate)A: 293TB: A431 C: H1299D: HeLa S3 E: Hep G2 F: MOLT4 G: Raji 7.5% SDS PAGEPrimary antibody diluted at 1: 1000)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using Complement C2 antibody at 1: 200 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using Complement C2 antibody at 1: 200 dilution.)
NCBI and Uniprot Product Information
NCBI Description
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
Uniprot Description
C2: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase. Defects in C2 are the cause of complement component 2 deficiency (C2D). A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.43; Protease
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: extracellular region; extracellular space
Molecular Function: metal ion binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, classical pathway; innate immune response; proteolysis; regulation of complement activation; response to nutrient
Disease: Complement Component 2 Deficiency; Macular Degeneration, Age-related, 14
Research Articles on C2
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Product Notes
The C2 c2 (Catalog #AAA9403665) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Complement C2 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement C2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200. Researchers should empirically determine the suitability of the C2 c2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement C2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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