Rabbit anti-Rat Collagen Type V Polyclonal Antibody | anti-COL5A2 antibody
Rabbit A' Rat Collagen Type V
Cross-reactivity (% @ 1:10 RIA dilution)
Rat Collagen Type V - 100%
Rat Collagen Types I, III - <0.1%
Rat Elastin - <0.1%
Reconstitute with 0.5ml deionized water.
IFA (with fluorescein anti-rabbit IgG conjugate): use diluted at >1:40 on frozen rat
Reconstituted: Aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices
By similarity.
Subunit structure: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta.
Subcellular location: Secreted › extracellular space › extracellular matrix
By similarity.
Domain: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function
By similarity.
Post-translational modification: Prolines at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Probably 3-hydroxylated on Pro-919 and Pro-1156 by LEPREL1.
Involvement in disease: Ehlers-Danlos syndrome 1 (EDS1) [MIM:130000]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15Ehlers-Danlos syndrome 2 (EDS2) [MIM:130010]: Mild form of classic Ehlers-Danlos syndrome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17
Sequence similarities: Belongs to the fibrillar collagen family.Contains 1 fibrillar collagen NC1 domain.Contains 1 VWFC domain.
Sequence caution: The sequence AAH43613.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAY24185.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAD92282.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on COL5A2
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Product Notes
The COL5A2 col5a2 (Catalog #AAA316298) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit A' Rat Collagen Type V reacts with Rat and may cross-react with other species as described in the data sheet. For immunostaining of extra or intracellular components in light microscopy. For the quantitation of Collagen Type II in biological fluids or in culture supernatants. IFA (with fluorescein anti-rabbit IgG conjugate): use diluted at >1:40 on frozen rat. Researchers should empirically determine the suitability of the COL5A2 col5a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Collagen Type V, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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