Rabbit anti-Human, Mouse COL19A1 Polyclonal Antibody | anti-COL19A1 antibody

COL19A1, NT (COL19A1, Collagen alpha-1(XIX) chain, Collagen alpha-1(Y) chain) (FITC)

Cat. Num. AAA6287617

• Gene Names: COL19A1; COL9A1L; D6S228E
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: COL19A1; Polyclonal Antibody; NT (COL19A1; Collagen alpha-1(XIX) chain; Collagen alpha-1(Y) chain) (FITC); Collagen alpha-1(Y) chain; anti-COL19A1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-COL19A1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: COL19A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 174-204 amino acids selected from the N-terminal region of human COL19A1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(COL19A1 Antibody (N-term) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the COL19A1 antibody detected the COL19A1 protein (arrow).)

Western Blot (WB)

(COL19A1 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the COL19A1 antibody detected the COL19A1 protein (arrow).)

Related Product Information for anti-COL19A1 antibody

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced.

Product Categories/Family for anti-COL19A1 antibody

Antibodies; Collagen

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010): Boudko, S.P., et al. J. Biol. Chem. 283(49):34345-34351(2008). Kapyla, J., et al. J. Biol. Chem. 279(49):51677-51687(2004). Mungall, A.J., et al. Nature 425(6960):805-811(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 47778921
• NCBI GeneID: 1310
• NCBI Accession #: NP_001849.2
• NCBI GenBank Nucleotide #: NM_001858.4
• UniProt Accession #: Q14993; Q00559; Q05850; Q12885; Q13676; Q14DH1; Q5JUF0; Q5T424; Q9H572; Q9NPZ2; Q9NQP2
• Molecular Weight: 115,221 Da
• NCBI Official Full Name: collagen alpha-1(XIX) chain
• NCBI Official Synonym Full Names: collagen, type XIX, alpha 1
• NCBI Official Symbol: COL19A1
• NCBI Official Synonym Symbols: COL9A1L; D6S228E
• NCBI Protein Information: collagen alpha-1(XIX) chain; collagen alpha-1(XIX) chain; collagen alpha-1(Y) chain; collagen alpha 1 (Y) chain; a1 chain of type XIX collagen; collagen XIX, alpha-1 polypeptide
• UniProt Protein Name: Collagen alpha-1(XIX) chain
• UniProt Gene Name: COL19A1
• UniProt Entry Name: COJA1_HUMAN

NCBI Description

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]

Uniprot Description

COL19A1: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 6q12-q13

Cellular Component: proteinaceous extracellular matrix; collagen; endoplasmic reticulum lumen; extracellular region

Molecular Function: protein binding, bridging; extracellular matrix structural constituent

Biological Process: collagen catabolic process; extracellular matrix disassembly; cell-cell adhesion; skeletal muscle development; extracellular matrix organization and biogenesis; cell adhesion; cell differentiation; skeletal development