Rabbit COG7 Polyclonal Antibody | anti-COG7 antibody

COG7 Rabbit Polyclonal

Cat. Num. AAA768063

• Gene Names: COG7; CDG2E
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: COG7; Polyclonal Antibody; COG7 Rabbit Polyclonal; anti-COG7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 770

• Applicable Applications for anti-COG7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Component of oligomeric golgi complex 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human cervical cancer using MBS768063 (COG7 antibody) at dilution of 1:100)

Western Blot (WB)

(Y79 cells were subjected to SDS PAGE followed by western blot with MBS768063 (COG7 antibody) at dilution of 1:400)

NCBI and Uniprot Product Information

• NCBI GI #: 23957690
• NCBI GeneID: 91949
• NCBI Accession #: NP_705831.1
• NCBI GenBank Nucleotide #: NM_153603.3
• Molecular Weight: 86,344 Da
• NCBI Official Full Name: conserved oligomeric Golgi complex subunit 7
• NCBI Official Synonym Full Names: component of oligomeric golgi complex 7
• NCBI Official Symbol: COG7
• NCBI Official Synonym Symbols: CDG2E
• NCBI Protein Information: conserved oligomeric Golgi complex subunit 7
• UniProt Protein Name: Conserved oligomeric Golgi complex subunit 7
• Protein Family: Conserved oligomeric Golgi complex
• UniProt Gene Name: COG7
• UniProt Synonym Gene Names: COG complex subunit 7
• UniProt Entry Name: COG7_HUMAN

NCBI Description

The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

Uniprot Description

COG7: Required for normal Golgi function. Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG7 family.

Chromosomal Location of Human Ortholog: 16p12.2

Cellular Component: Golgi apparatus; Golgi membrane; Golgi transport complex; intracellular membrane-bound organelle; nucleolus; trans-Golgi network membrane

Molecular Function: protein binding

Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; intracellular protein transport; protein amino acid glycosylation; protein localization in Golgi apparatus; protein localization in organelle; protein stabilization; retrograde vesicle-mediated transport, Golgi to ER

Disease: Congenital Disorder Of Glycosylation, Type Iie