Rabbit CNP Polyclonal Antibody | anti-CNP antibody

CNP Antibody (C-Term)

Cat. Num. AAA9215862

• Gene Names: CNP; CNP1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Synonyms: CNP; Polyclonal Antibody; CNP Antibody (C-Term); Purified Rabbit Polyclonal Antibody (Pab); 2'; 3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase; anti-CNP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This CNP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 122-156 amino acids from human CNP.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 421

• Applicable Applications for anti-CNP antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000; WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-CNP Antibody (C-Term) at 1:2000 dilutionLane 1: mouse brain lysatesLane 2: rat brain lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 48 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot (WB)

(All lanes : Anti-CNP Antibody (C-Term) at 1:2000 dilutionLane 1: human brain lysatesLane 2: human cerebellum lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 48 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-CNP antibody

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Product Categories/Family for anti-CNP antibody

Crown Antibodies; Neuroscience

References

Thompson R.J.,et al.Biochem. Soc. Trans. 20:621-626(1992). Kurihara T.,et al.Biochem. Biophys. Res. Commun. 152:837-842(1988). Monoh K.,et al.Gene 129:297-301(1993). Douglas A.J.,et al.Ann. Hum. Genet. 56:243-254(1992). Zody M.C.,et al.Nature 440:1045-1049(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 94721261
• NCBI GeneID: 1267
• NCBI Accession #: NP_149124.3
• NCBI GenBank Nucleotide #: NM_033133.4
• UniProt Accession #: P09543
• Molecular Weight: 47579
• NCBI Official Full Name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• NCBI Official Synonym Full Names: 2',3'-cyclic nucleotide 3' phosphodiesterase
• NCBI Official Symbol: CNP
• NCBI Official Synonym Symbols: CNP1
• NCBI Protein Information: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• UniProt Protein Name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• Protein Family: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• UniProt Gene Name: CNP
• UniProt Synonym Gene Names: CNP; CNPase
• UniProt Entry Name: CN37_HUMAN

NCBI Description

CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphodiesterase; EC 3.1.4.37; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; extracellular space; microtubule; mitochondrial outer membrane; microvillus; membrane; perinuclear region of cytoplasm; mitochondrial inner membrane; cytoplasm; melanosome; plasma membrane; pseudopodium; nucleus

Molecular Function: cyclic nucleotide binding; RNA binding; 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Biological Process: synaptic transmission; substantia nigra development; axonogenesis; adult locomotory behavior; response to toxin; forebrain development; oligodendrocyte differentiation; response to lipopolysaccharide; regulation of mitochondrial membrane permeability; microtubule cytoskeleton organization and biogenesis; cyclic nucleotide catabolic process; aging

Uniprot Description

CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.37; Cell development/differentiation; Phosphodiesterase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; extracellular space; melanosome; membrane; microtubule; microvillus; mitochondrial inner membrane; mitochondrial outer membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; pseudopodium

Molecular Function: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; cyclic nucleotide binding; RNA binding

Biological Process: adult locomotory behavior; aging; axonogenesis; cyclic nucleotide catabolic process; forebrain development; microtubule cytoskeleton organization and biogenesis; oligodendrocyte differentiation; regulation of mitochondrial membrane permeability; response to lipopolysaccharide; response to toxin; substantia nigra development; synaptic transmission