Western Blot (WB)
(Western blot analysis of CNOT7 expression in HeLa (A), HuvEc (B), DKD (C), mouse brain (D), rat brain (E) whole cell lysates.)
Rabbit CNOT7 Polyclonal Antibody | anti-CNOT7 antibody
Anti-CNOT7 Antibody
Western Blot (WB)
(Western blot analysis of CNOT7 expression in HeLa (A), HuvEc (B), DKD (C), mouse brain (D), rat brain (E) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of CNOT7 expression in HeLa (A), HuvEc (B), DKD (C), mouse brain (D), rat brain (E) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of CNOT7 staining in human ovarian cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of CNOT7 staining in human ovarian cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
Uniprot Description
CNOT7: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression. Belongs to the CAF1 family.
Protein type: EC 3.1.13.4; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 8p22-p21.3
Cellular Component: CCR4-NOT complex; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: 3'-5'-exoribonuclease activity; exoribonuclease activity; poly(A)-specific ribonuclease activity; protein binding; signal transducer activity; transcription factor activity
Biological Process: carbohydrate metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; miRNA-mediated gene silencing; negative regulation of cell proliferation; poly(A) tail shortening; positive regulation of cell proliferation; RNA-mediated gene silencing; signal transduction
Research Articles on CNOT7
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Product Notes
The CNOT7 cnot7 (Catalog #AAA8248133) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CNOT7 Antibody reacts with Human, Mouse, Rat, Bovine, Chicken, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's CNOT7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1/500 - 1/2000; Immunohistochemistry: 1/50 - 1/200. Researchers should empirically determine the suitability of the CNOT7 cnot7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNOT7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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