Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MBS7126987(CNGA1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200))
Rabbit anti-Human CNGA1 Polyclonal Antibody | anti-CNGA1 antibody
CNGA1 Antibody
IHC: 1:25-1:100
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MBS7126987(CNGA1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MBS7126987(CNGA1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Description
CNGA1: a cyclic nucleotide-gated cation channel of rod cells in the retina. Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. CNG ion channels exist in the retinal, olfactory and cochlear sensory neurons.
Protein type: Channel, cation; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: voltage-gated potassium channel activity; protein binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of membrane potential; regulation of rhodopsin mediated signaling; visual perception; transport
Disease: Retinitis Pigmentosa 49; Retinitis Pigmentosa
Research Articles on CNGA1
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Product Notes
The CNGA1 cnga1 (Catalog #AAA7126987) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CNGA1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CNGA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:500-1:5000 IHC: 1:25-1:100. Researchers should empirically determine the suitability of the CNGA1 cnga1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNGA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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