Testing Data
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Rabbit anti-Human CLSPN Polyclonal Antibody | anti-CLSPN antibody
CLSPN Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Testing Data
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Testing Data
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Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS768007 (Claspin antibody) at dilution of 1:300)
Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS768007 (Claspin antibody) at dilution of 1:300)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Description
claspin: required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Interacts with CHEK1 when phosphorylated. Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation. Interacts with BRCA1 and this interaction increases during checkpoint activation.
Protein type: Actin-binding; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: DNA binding; protein binding
Biological Process: activation of protein kinase activity; cell structure disassembly during apoptosis; DNA damage checkpoint; DNA repair; DNA replication; G2/M transition DNA damage checkpoint; mitotic cell cycle DNA replication checkpoint; peptidyl-serine phosphorylation
Research Articles on CLSPN
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Product Notes
The CLSPN clspn (Catalog #AAA768007) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLSPN Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLSPN can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the CLSPN clspn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLSPN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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