Rabbit anti-Human CLN5 Polyclonal Antibody | anti-CLN5 antibody

CLN5, NT (Ceroid-lipofuscinosis Neuronal Protein 5, Protein CLN5)

Cat. Num. AAA628535

• Gene Names: CLN5; NCL; FLJ90628
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CLN5; Polyclonal Antibody; NT (Ceroid-lipofuscinosis Neuronal Protein 5; Protein CLN5); Anti -CLN5; anti-CLN5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CLN5.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-CLN5 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1000; Western Blot: 1:100-1:500
• Immunogen: KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa48-77 in the N-terminal region of human CLN5.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of CLN5 Antibody (N-term) in T47D cell line lysates (35ug/lane).CLN5 (arrow) was detected using the purified Pab.)

Related Product Information for anti-CLN5 antibody

CLN5 is involved in the degradation of post-translationally modified proteins in lysosomes.

Product Categories/Family for anti-CLN5 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 5729772
• NCBI GeneID: 1203
• NCBI Accession #: NP_006484.1
• NCBI GenBank Nucleotide #: NM_006493.2
• UniProt Accession #: O75503
• Molecular Weight: 41,497 Da
• NCBI Official Full Name: ceroid-lipofuscinosis neuronal protein 5
• NCBI Official Synonym Full Names: ceroid-lipofuscinosis, neuronal 5
• NCBI Official Symbol: CLN5
• NCBI Official Synonym Symbols: NCL; FLJ90628
• NCBI Protein Information: ceroid-lipofuscinosis neuronal protein 5; OTTHUMP00000018521
• UniProt Protein Name: Ceroid-lipofuscinosis neuronal protein 5
• Protein Family: Cln5-like protein
• UniProt Gene Name: CLN5
• UniProt Entry Name: CLN5_HUMAN

NCBI Description

This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.

Uniprot Description

CLN5: Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis type 5 (CLN5); also known as Finnish variant late-infantile neuronal ceroid lipofuscinosis (vLINCL). A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 5 comprise mixed combinations of granular, curvilinear, and fingerprint profiles. Belongs to the CLN5 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q21.1-q32

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; lysosome; lysosomal membrane; endoplasmic reticulum; integral to membrane

Molecular Function: mannose binding; protein binding

Biological Process: signal peptide processing; neurogenesis; lysosomal lumen acidification; protein catabolic process; brain development; neuron maturation

Disease: Ceroid Lipofuscinosis, Neuronal, 5