Western Blot (WB)
(Sample Type: Human HMEC-1Sample type: human microvascular endothelial cells (25ug)Primary Dilution: 1:1000Secondary Antibody: Goat anti-Rabbit-HRPSecondary Dilution: 1:5000Image Submitted by: Andreas Eisenreich Charite Universitatsmedizin Berlin )
Rabbit CLK4 Polyclonal Antibody | anti-CLK4 antibody
CLK4 antibody - N-terminal region
Western Blot (WB)
(Sample Type: Human HMEC-1Sample type: human microvascular endothelial cells (25ug)Primary Dilution: 1:1000Secondary Antibody: Goat anti-Rabbit-HRPSecondary Dilution: 1:5000Image Submitted by: Andreas Eisenreich Charite Universitatsmedizin Berlin )
Western Blot (WB)
(Sample Type: Human HMEC-1Sample type: human microvascular endothelial cells (25ug)Primary Dilution: 1:1000Secondary Antibody: Goat anti-Rabbit-HRPSecondary Dilution: 1:5000Image Submitted by: Andreas Eisenreich Charite Universitatsmedizin Berlin )
Target Description: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
CLK4: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. It has been reported to regulate splicing of genes such as Tau exon 10 in the mammalian nervous system. Expressed in liver, kidney, heart, muscle and brain. Clk4 mRNAs were expressed in the hippocampus, the cerebellum, and the olfactory bulb.
Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; CMGC group; CLK family
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: nucleus
Molecular Function: protein serine/threonine kinase activity; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation
Research Articles on CLK4
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Product Notes
The CLK4 clk4 (Catalog #AAA3200267) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLK4 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast and may cross-react with other species as described in the data sheet. AAA Biotech's CLK4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CLK4 clk4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: RSRRSSPKRK RNRHCSSHQS RSKSHRRKRS RSIEDDEEGH LICQSGDVLR. It is sometimes possible for the material contained within the vial of "CLK4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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