Rabbit anti-Human CLEC6A Polyclonal Antibody | anti-CLEC6A antibody

CLEC6A, CT (CLEC6A, CLECSF10, DECTIN2, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dendritic cell-associated C-type lectin 2)

Cat. Num. AAA6009500

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CLEC6A; Polyclonal Antibody; CT (CLEC6A; CLECSF10; DECTIN2; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2); Anti -CLEC6A; anti-CLEC6A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-CLEC6A antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: CLEC6A antibody is generated from rabbits immunized with a KLH conjugated synthetic between 136-163 amino acids selected from the C-terminal region of human CLEC6A.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CLEC6A Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the CLEC6A antibody detected the CLEC6A protein (arrow).)

Related Product Information for anti-CLEC6A antibody

Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).

Product Categories/Family for anti-CLEC6A antibody

Antibodies; Abs to Lectins

NCBI and Uniprot Product Information

• NCBI GI #: 77735909
• NCBI GeneID: 514979
• NCBI Accession #: NP_001029651.1
• NCBI GenBank Nucleotide #: NM_001034479.1
• UniProt Accession #: Q3LUH2; Q3LUH1
• Molecular Weight: 23,738 Da
• NCBI Official Full Name: C-type lectin domain family 6 member A
• NCBI Official Symbol: CLEC6A
• NCBI Protein Information: C-type lectin domain family 6 member A; dectin-2; DC-associated C-type lectin 2; dendritic cell-associated C-type lectin 2
• UniProt Protein Name: C-type lectin domain family 6 member A
• Protein Family: C-type lectin domain family
• UniProt Gene Name: CLEC6A
• UniProt Synonym Gene Names: DECTIN2; DC-associated C-type lectin 2; Dectin-2
• UniProt Entry Name: CLC6A_BOVIN

Uniprot Description

Function: Binds high-mannose carbohydrates in a Ca2+-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway

By similarity.

Subunit structure: Associated with FCER1G

By similarity.

Subcellular location: Membrane; Single-pass type II membrane protein

Probable.

Tissue specificity: Expressed at the highest levels in lymph nodes, at moderate levels in skin, small intestine, liver, and lung, and at lower levels in abomasum and spleen, but is not in the brain. Abundantly expressed by Langerhans cells compared to macrophages. Ref.1

Sequence similarities: Contains 1 C-type lectin domain.