Rabbit anti-Human CLEC4M Polyclonal Antibody | anti-CLEC4M antibody

CLEC4M Rabbit Polyclonal

Cat. Num. AAA767989

• Gene Names: CLEC4M; CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CLEC4M; Polyclonal Antibody; CLEC4M Rabbit Polyclonal; anti-CLEC4M antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 332

• Applicable Applications for anti-CLEC4M antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Immunogen: C-type lectin domain family 4, member M
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using MBS767989 (CLEC4M Antibody) at dilution of 1:50)

Western Blot (WB)

(Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS767989 (CLEC4M Antibody) at dilution of 1:3000)

NCBI and Uniprot Product Information

• NCBI GI #: 223278342
• NCBI GeneID: 10332
• NCBI Accession #: NP_001138379.1
• NCBI GenBank Nucleotide #: NM_001144907.1
• Molecular Weight: 24,408 Da
• NCBI Official Full Name: C-type lectin domain family 4 member M isoform 11
• NCBI Official Synonym Full Names: C-type lectin domain family 4 member M
• NCBI Official Symbol: CLEC4M
• NCBI Official Synonym Symbols: CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR
• NCBI Protein Information: C-type lectin domain family 4 member M
• UniProt Protein Name: C-type lectin domain family 4 member M
• Protein Family: C-type lectin domain family
• UniProt Gene Name: CLEC4M
• UniProt Synonym Gene Names: CD209L; CD209L1; CD299; DC-SIGNR; DC-SIGN2; L-SIGN
• UniProt Entry Name: CLC4M_HUMAN

NCBI Description

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Uniprot Description

CLEC4M: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cytoplasm; extracellular region; integral to plasma membrane; membrane

Molecular Function: calcium-dependent protein binding; carbohydrate binding; ICAM-3 receptor activity; mannose binding; metal ion binding; peptide antigen binding; receptor activity; viral receptor activity; virion binding

Biological Process: adaptive immune response; antigen processing and presentation; cell-cell recognition; endocytosis; entry of virus into host cell; innate immune response; leukocyte adhesion; peptide antigen transport; regulation of blood coagulation; regulation of gene expression; viral genome replication; virion attachment to host cell surface receptor; virus-host interaction