Goat CLCN2 Polyclonal Antibody | anti-CLCN2 antibody

Goat Polyclonal to Human CLCN2

Cat. Num. AAA243614

• Gene Names: CLCN2; CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2
• Reactivity: Gibbon, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CLCN2; Polyclonal Antibody; Goat Polyclonal to Human CLCN2; Anti-CLCN2 Antibody (aa738-751) IHC-plus; Chloride channel protein 2; Chloride channel 2; ClC-2; CIC-2; CLC2; EGI3; EJM6; ECA2; ECA3; EGMA; EJM8; EGI11; Human CLCN2; anti-CLCN2 antibody

• Host: Goat
• Reactivity: Gibbon, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CLCN2. This antibody is expected to recognize all reported isoforms (NP_004357.3; NP_001164558.1; NP_001164559.1; NP_001164560.1).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 898

• Applicable Applications for anti-CLCN2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 - 7.5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide SEKLESCEKRKLKR from an internal region of human CLCN2 (NP_004357.3). Percent identity by BLAST analysis: Human, Gibbon, Monkey (100%); Marmoset (93%); Dog (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: CLCN2 antibody was raised against synthetic peptide SEKLESCEKRKLKR from an internal region of human CLCN2 (NP_004357.3). Percent identity by BLAST analysis: Human, Gibbon, Monkey (100%); Marmoset (93%); Dog (86%).
• Antigen Modification: aa738-751
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-CLCN2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Related Product Information for anti-CLCN2 antibody

Clcn2, a member of the CLC chloride channel subfamily, has been implicated in the regulation of cell volume and neuronal excitability.

Product Categories/Family for anti-CLCN2 antibody

Family: Ion channel; Subfamily: Chloride channel - CLC

NCBI and Uniprot Product Information

• NCBI GI #: 156104869
• NCBI GeneID: 1181
• NCBI Accession #: NP_004357.3
• NCBI GenBank Nucleotide #: NM_004366.5
• UniProt Accession #: P51788; O14864; Q6IPA9; Q8WU13; B4DQT9; B4DZ58; E9PBD9; E9PCD2
• Molecular Weight: 95,399 Da
• NCBI Official Full Name: chloride channel protein 2 isoform 1
• NCBI Official Synonym Full Names: chloride channel, voltage-sensitive 2
• NCBI Official Symbol: CLCN2
• NCBI Official Synonym Symbols: CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2
• NCBI Protein Information: chloride channel protein 2; chloride channel 2
• UniProt Protein Name: Chloride channel protein 2
• Protein Family: Chloride channel protein
• UniProt Gene Name: CLCN2
• UniProt Synonym Gene Names: ClC-2
• UniProt Entry Name: CLCN2_HUMAN

NCBI Description

This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

CLCN2: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN2 are associated with susceptibility to epilepsy, idiopathic generalized type 11 (EIG11). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2). JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening and myoclonic seizures. Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, chloride; Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: plasma membrane

Molecular Function: voltage-gated chloride channel activity

Biological Process: retina development in camera-type eye; transport; transmembrane transport

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 11; Leukoencephalopathy With Ataxia