Rabbit anti-Human CKBB Polyclonal Antibody | anti-CKBB antibody

CKBB antibody

Cat. Num. AAA535375

• Gene Names: CKB; BCK; B-CK; CKBB; HEL-211; HEL-S-29
• Reactivity: Human
• Applications: User optimized
• Synonyms: CKBB; Polyclonal Antibody; CKBB antibody; Polyclonal CKBB; Anti-CKBB; Creatine Kinase BB Isoenzyme; CK BB; anti-CKBB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human
• Form/Format: Neat serum with no preservatives.
• Sequence Length: 381

• Applicable Applications for anti-CKBB antibody: User optimized
• Biological Significance: In the cells, the "cytosolic" creatine kinase (CK) enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes: CK-MM, CK-BB and CK-MB. The genes for these subunits are located on different chromosomes: B on 14q32 and M on 19q13. In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form.
• Cross-Reactivity: CK-BB: 100%, CK-MB: 50%, CK-MM: 0%
• Immunogen: CKBB antibody was raised in rabbit using human CKBB from the brain as the immunogen.
• Preparation and Storage: Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles

Related Product Information for anti-CKBB antibody

Rabbit polyclonal CKBB antibody

Product Categories/Family for anti-CKBB antibody

Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 21536286
• NCBI GeneID: 1152
• NCBI Accession #: NP_001814.2
• NCBI GenBank Nucleotide #: NM_001823.4
• Molecular Weight: 42,644 Da
• NCBI Official Full Name: creatine kinase B-type
• NCBI Official Synonym Full Names: creatine kinase, brain
• NCBI Official Symbol: CKB
• NCBI Official Synonym Symbols: BCK; B-CK; CKBB; HEL-211; HEL-S-29
• NCBI Protein Information: creatine kinase B-type
• UniProt Protein Name: Creatine kinase B-type
• UniProt Gene Name: CKB
• UniProt Synonym Gene Names: CKBB
• UniProt Entry Name: KCRB_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

CKB: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: Kinase, other; Amino Acid Metabolism - arginine and proline; EC 2.7.3.2

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: mitochondrion; cytosol

Molecular Function: protein binding; creatine kinase activity; ATP binding

Biological Process: substantia nigra development; creatine metabolic process; phosphorylation; cellular chloride ion homeostasis