Rabbit anti-Human CIT Polyclonal Antibody | anti-CIT antibody

CIT, CT (Citron Rho-interacting Kinase, CRIK, Serine/Threonine-protein Kinase 21, KIAA0949, STK21)

Cat. Num. AAA641753

• Gene Names: CIT; CRIK; STK21
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CIT; Polyclonal Antibody; CT (Citron Rho-interacting Kinase; CRIK; Serine/Threonine-protein Kinase 21; KIAA0949; STK21); Anti -CIT; anti-CIT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CIT.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-CIT antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human CIT (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CIT antibody

CIT is a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. This protein exhibits dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. CIT plays an important role in the regulation of cytokinesis and the development of the central nervous system.

Product Categories/Family for anti-CIT antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 332801082
• NCBI GeneID: 11113
• NCBI Accession #: NP_001193928.1
• NCBI GenBank Nucleotide #: NM_001206999.1
• UniProt Accession #: O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7
• Molecular Weight: 231,431 Da
• NCBI Official Full Name: citron Rho-interacting kinase isoform 1
• NCBI Official Synonym Full Names: citron (rho-interacting, serine/threonine kinase 21)
• NCBI Official Symbol: CIT
• NCBI Official Synonym Symbols: CRIK; STK21
• NCBI Protein Information: citron Rho-interacting kinase; serine/threonine-protein kinase 21
• UniProt Protein Name: Citron Rho-interacting kinase
• Protein Family: Citrate
• UniProt Gene Name: CIT
• UniProt Synonym Gene Names: CRIK; KIAA0949; STK21; CRIK
• UniProt Entry Name: CTRO_HUMAN

NCBI Description

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

CRIK: an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described.

Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: ruffle; Golgi cisterna; membrane; cell soma; plasma membrane; vacuole; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; SH3 domain binding; ATP binding; PDZ domain binding

Biological Process: positive regulation of cytokinesis; mitosis; mitotic sister chromatid segregation; regulation of actin polymerization and/or depolymerization; cytokinesis; negative regulation of dendrite morphogenesis; protein amino acid phosphorylation; generation of neurons; regulation of catalytic activity; dendrite development; spermatogenesis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; mitotic metaphase/anaphase transition