Western Blot (WB)
(Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody (C-term). MBS9204615 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Rabbit anti-Human CIR Polyclonal Antibody | anti-CIR1 antibody
CIR Antibody (C-term)
Gene Names
CIR1; CIR
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CIR; Polyclonal Antibody; CIR Antibody (C-term); Corepressor interacting with RBPJ 1; CBF1-interacting corepressor; Recepin; CIR1; anti-CIR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the C-terminal region of human CIR.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
396-424
Sequence Length
202
Applicable Applications for anti-CIR1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Crown Antibody
Yes
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody (C-term). MBS9204615 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody (C-term). MBS9204615 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Related Product Information for anti-CIR1 antibody
CIR may modulate splice site selection during alternative splicing of pre-mRNAs. It regulates transcription and acts as corepressor for RBPSUH. It recruits RBPSUH to the Sin3-histone deacetylase complex (HDAC), and is required for RBPSUH-mediated repression of transcription.
Product Categories/Family for anti-CIR1 antibody
References
Olsen,J.V., Cell 127 (3), 635-648 (2006)
Maita,H., Exp. Cell Res. 303 (2), 375-387 (2005)
Zhou,S., Mol. Cell. Biol. 21 (18), 6222-6232 (2001)
Maita,H., Exp. Cell Res. 303 (2), 375-387 (2005)
Zhou,S., Mol. Cell. Biol. 21 (18), 6222-6232 (2001)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52313
NCBI Official Full Name
corepressor interacting with RBPJ 1
NCBI Official Synonym Full Names
corepressor interacting with RBPJ, 1
NCBI Official Symbol
CIR1
NCBI Official Synonym Symbols
CIR
NCBI Protein Information
corepressor interacting with RBPJ 1
UniProt Protein Name
Corepressor interacting with RBPJ 1
Protein Family
UniProt Gene Name
CIR1
UniProt Synonym Gene Names
CIR
UniProt Entry Name
CIR1_HUMAN
Uniprot Description
CIR: May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytoplasm; histone deacetylase complex; microtubule organizing center; nuclear speck; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; RNA splicing; mRNA processing; negative regulation of transcription, DNA-dependent
Research Articles on CIR1
Similar Products
Product Notes
The CIR1 cir1 (Catalog #AAA9204615) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 396-424. The CIR Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CIR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CIR1 cir1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CIR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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