Western Blot (WB)
(Western blot (WB) analysis of CHSY1 polyclonal antibody at 1:500 dilutionLaneA: HEK293T whole cell lysateLaneB: PC12 whole cell lysateLaneC: AML-12 whole cell lysate)
Rabbit CHSY1 Polyclonal Antibody | anti-CHSY1 antibody
CHSY1 polyclonal antibody
IHC: 1:50~1:200
Western Blot (WB)
(Western blot (WB) analysis of CHSY1 polyclonal antibody at 1:500 dilutionLaneA: HEK293T whole cell lysateLaneB: PC12 whole cell lysateLaneC: AML-12 whole cell lysate)
Western Blot (WB)
(Western blot (WB) analysis of CHSY1 polyclonal antibody at 1:500 dilutionLaneA: HEK293T whole cell lysateLaneB: PC12 whole cell lysateLaneC: AML-12 whole cell lysate)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]
Uniprot Description
CHSY1: Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Defects in CHSY1 are the cause of Temtamy preaxial brachydactyly syndrome (TPBS). A syndrome characterized by multiple congenital anomalies, mental retardation, sensorineural deafness, talon cusps of upper central incisors, growth retardation, and bilateral symmetric digital anomalies mainly in the form of preaxial brachydactyly and hyperphalangism. Belongs to the chondroitin N- acetylgalactosaminyltransferase family.
Protein type: EC 2.4.1.175; EC 2.4.1.226; Transferase; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: Golgi membrane; membrane; integral to membrane; extracellular region
Molecular Function: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; metal ion binding; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
Biological Process: response to nutrient levels; chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; sulfation; negative regulation of ossification; positive regulation of smoothened signaling pathway; pathogenesis; chondrocyte development; proximal/distal pattern formation
Disease: Temtamy Preaxial Brachydactyly Syndrome
Research Articles on CHSY1
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Product Notes
The CHSY1 chsy1 (Catalog #AAA3014798) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CHSY1 polyclonal antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CHSY1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500~1:1000 IHC: 1:50~1:200. Researchers should empirically determine the suitability of the CHSY1 chsy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHSY1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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