Western Blot (WB)
(Western blot analysis of lysate from K562 cell line, using CHST11 Antibody (Center). MBS9209130 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)
Rabbit CHST11 Polyclonal Antibody | anti-CHST11 antibody
CHST11 Antibody (Center)
Western Blot (WB)
(Western blot analysis of lysate from K562 cell line, using CHST11 Antibody (Center). MBS9209130 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)
Western Blot (WB)
(Western blot analysis of lysate from K562 cell line, using CHST11 Antibody (Center). MBS9209130 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)
Hiraoka N.,et al.J. Biol. Chem. 275:20188-20196(2000).
Xia G.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
CHST11: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH. Belongs to the sulfotransferase 2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; Energy Metabolism - sulfur; Membrane protein, integral; EC 2.8.2.5; Glycan Metabolism - chondroitin sulfate biosynthesis
Chromosomal Location of Human Ortholog: 12q
Cellular Component: Golgi membrane; Golgi apparatus; membrane; integral to membrane
Molecular Function: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activity; chondroitin 4-sulfotransferase activity
Biological Process: developmental growth; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; polysaccharide localization; pathogenesis; respiratory gaseous exchange; embryonic viscerocranium morphogenesis; chondrocyte development; carbohydrate biosynthetic process; regulation of cell proliferation; post-embryonic development; chondroitin sulfate metabolic process; carbohydrate metabolic process; embryonic digit morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of apoptosis
Research Articles on CHST11
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Product Notes
The CHST11 chst11 (Catalog #AAA9209130) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CHST11 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CHST11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CHST11 chst11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHST11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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