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Western Blot (WB) (Western blot analysis of hromogranin-C Antibody (Center) in Ramos cell line lysates (35ug/lane). SCG2 (arrow) was detected using the purified Pab.)

Rabbit Chromogranin-C Polyclonal Antibody | anti-SCG2 antibody

Chromogranin-C Antibody (Center)

Gene Names
SCG2; SN; CHGC; EM66; SgII
Reactivity
Human (Predicted Reactivity: Pig)
Applications
Western Blot, ELISA, Immunohistochemistry
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Chromogranin-C; Polyclonal Antibody; Chromogranin-C Antibody (Center); Secretogranin-2; Secretogranin II; SgII; Secretoneurin; SN; SCG2; CHGC; anti-SCG2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Pig)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Chromogranin-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the Central region of human Chromogranin-C.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
246-274
Sequence Length
617
Applicable Applications for anti-SCG2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of hromogranin-C Antibody (Center) in Ramos cell line lysates (35ug/lane). SCG2 (arrow) was detected using the purified Pab.)

Western Blot (WB) (Western blot analysis of hromogranin-C Antibody (Center) in Ramos cell line lysates (35ug/lane). SCG2 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Chromogranin-C Antibody (Center) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the Chromogranin-C Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (Chromogranin-C Antibody (Center) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the Chromogranin-C Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-SCG2 antibody
Chromogranin-C is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.
Product Categories/Family for anti-SCG2 antibody
References
Li,L., et.al., Cell Death Differ. 15 (5), 879-888 (2008)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
70941
NCBI Official Full Name
secretogranin-2
NCBI Official Synonym Full Names
secretogranin II
NCBI Official Symbol
SCG2
NCBI Official Synonym Symbols
SN; CHGC; EM66; SgII
NCBI Protein Information
secretogranin-2
UniProt Protein Name
Secretogranin-2
Protein Family
UniProt Gene Name
SCG2
UniProt Synonym Gene Names
CHGC; SgII; SN
UniProt Entry Name
SCG2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

Uniprot Description

SCG2: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. Belongs to the chromogranin/secretogranin protein family.

Protein type: Secreted; Cytokine; Cell cycle regulation; Apoptosis; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: extracellular space; secretory granule

Molecular Function: cytokine activity; chemoattractant activity

Biological Process: positive chemotaxis; negative regulation of endothelial cell proliferation; MAPKKK cascade; eosinophil chemotaxis; protein secretion; endothelial cell migration; positive regulation of endothelial cell proliferation; angiogenesis; inflammatory response; induction of positive chemotaxis

Research Articles on SCG2

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Product Notes

The SCG2 scg2 (Catalog #AAA9213152) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 246-274. The Chromogranin-C Antibody (Center) reacts with Human (Predicted Reactivity: Pig) and may cross-react with other species as described in the data sheet. AAA Biotech's Chromogranin-C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the SCG2 scg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Chromogranin-C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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