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Western Blot (WB)

Rabbit anti-Human, Mouse CHRM4 Polyclonal Antibody | anti-CHRM4 antibody

CHRM4

Gene Names
CHRM4; HM4; M4R
Reactivity
Human, Mouse
Applications
Western Blot
Synonyms
CHRM4; Polyclonal Antibody; anti-CHRM4 antibody
Ordering
 
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For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Sequence Length
479
Applicable Applications for anti-CHRM4 antibody
Western Blot (WB)
Species
Human
Route
Synthetic Peptide

Western Blot (WB)

(Western blot analysis of extracts of NIH/3T3 cells, using CHRM4 antibody.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.)

Product Categories/Family for anti-CHRM4 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
479
NCBI Official Full Name
Muscarinic acetylcholine receptor M4
NCBI Official Synonym Full Names
cholinergic receptor, muscarinic 4
NCBI Official Symbol
CHRM4
NCBI Official Synonym Symbols
HM4; M4R
NCBI Protein Information
muscarinic acetylcholine receptor M4; acetylcholine receptor, muscarinic 4
UniProt Protein Name
Muscarinic acetylcholine receptor M4
Protein Family
UniProt Gene Name
CHRM4
UniProt Entry Name
ACM4_HUMAN

NCBI Description

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

Uniprot Description

mAChR M4: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 11p12-p11.2

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: G-protein coupled acetylcholine receptor activity

Biological Process: regulation of locomotion; cell proliferation; acetylcholine receptor signaling, muscarinic pathway; cell surface receptor linked signal transduction; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; signal transduction

Research Articles on CHRM4

1. This study identify suppression of the PVHSIM1-->PAGvl/DR circuit connection as sufficient to induce overeating behavior.

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Product Notes

The CHRM4 chrm4 (Catalog #AAA126750) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CHRM4 reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CHRM4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CHRM4 chrm4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHRM4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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