Rabbit anti-Human CHRFAM7A Polyclonal Antibody | anti-CHRFAM7A antibody

CHRFAM7A (CHRNA7-FAM7A fusion Protein, CHRNA7-DR1, D-10, CHRFAM7A) (PE)

Cat. Num. AAA6455105

• Gene Names: CHRFAM7A; D-10; CHRNA7; CHRNA7-DR1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CHRFAM7A; Polyclonal Antibody; CHRFAM7A (CHRNA7-FAM7A fusion Protein; CHRNA7-DR1; D-10; CHRFAM7A) (PE); anti-CHRFAM7A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CHRFAM7A. Species Crossreactivity: human
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-CHRFAM7A antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa317-349 from human CHRFAM7A.
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-CHRFAM7A antibody

Antibodies; Receptors; Cholinergic

References

Ota T., et al. Nat. Genet. 36:40-45(2004). Zody M.C., et al. Nature 440:671-675(2006). Gault J., et al. Genomics 52:173-185(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 91208254
• NCBI GeneID: 89832
• UniProt Accession #: Q494W8; A8KAB9
• Molecular Weight: 321
• NCBI Official Full Name: CHRNA7-FAM7A fusion protein
• NCBI Official Synonym Full Names: CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
• NCBI Official Symbol: CHRFAM7A
• NCBI Official Synonym Symbols: D-10; CHRNA7; CHRNA7-DR1
• NCBI Protein Information: CHRNA7-FAM7A fusion protein; alpha-7 nicotinic cholinergic receptor subunit; alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid; CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similari
• UniProt Protein Name: CHRNA7-FAM7A fusion protein
• Protein Family: CHRNA7-FAM7A fusion protein
• UniProt Gene Name: CHRFAM7A
• UniProt Entry Name: CRFM7_HUMAN

NCBI Description

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

Uniprot Description

CHRFAM7A: Belongs to the ligand-gated ion channel (TC 1.A.9) family

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q13.1

Cellular Component: integral to membrane

Molecular Function: extracellular ligand-gated ion channel activity