Rabbit anti-Human CHORDC1 Polyclonal Antibody | anti-CHORDC1 antibody

CHORDC1, ID (CHORDC1, CHP1, Cysteine and histidine-rich domain-containing protein 1, CHORD domain-containing protein 1, Protein morgana) (FITC)

Cat. Num. AAA6285736

• Gene Names: CHORDC1; CHP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CHORDC1; Polyclonal Antibody; ID (CHORDC1; CHP1; Cysteine and histidine-rich domain-containing protein 1; CHORD domain-containing protein 1; Protein morgana) (FITC); Protein morgana; anti-CHORDC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-CHORDC1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CHORDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human CHORDC1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CHORDC1 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CHORDC1 antibody detected the CHORDC1 protein (arrow).)

Related Product Information for anti-CHORDC1 antibody

CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1 (By similarity).

Product Categories/Family for anti-CHORDC1 antibody

Antibodies; Amino Acids

References

Gano, J.J., et al. Mol. Cell Proteomics 9(2):255-270(2010). Lamesch, P., et al. Genomics 89(3):307-315(2007). Wu, J., et al. FEBS Lett. 579(2):421-426(2005). Brancaccio, M., et al. FEBS Lett. 551 (1-3), 47-52 (2003): Shirasu, K., et al. Cell 99(4):355-366(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 221316566
• NCBI GeneID: 26973
• NCBI Accession #: NP_036256.2
• NCBI GenBank Nucleotide #: NM_012124.2
• UniProt Accession #: Q9UHD1; Q6IN49; Q8WVL9; Q9H3D6; B2R6P8
• Molecular Weight: 35,286 Da
• NCBI Official Full Name: cysteine and histidine-rich domain-containing protein 1 isoform a
• NCBI Official Synonym Full Names: cysteine and histidine-rich domain (CHORD) containing 1
• NCBI Official Symbol: CHORDC1
• NCBI Official Synonym Symbols: CHP1
• NCBI Protein Information: cysteine and histidine-rich domain-containing protein 1; CHP-1; protein morgana; CHORD-containing protein 1; chord domain-containing protein 1; cysteine and histidine-rich domain (CHORD)-containing 1; cysteine and histidine-rich domain (CHORD)-containing,
• UniProt Protein Name: Cysteine and histidine-rich domain-containing protein 1
• Protein Family: Cysteine and histidine-rich domain-containing protein
• UniProt Gene Name: CHORDC1
• UniProt Synonym Gene Names: CHP1; CHORD-containing protein 1; CHP-1
• UniProt Entry Name: CHRD1_HUMAN

Uniprot Description

CHORDC1: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 11q14.3

Molecular Function: protein binding; zinc ion binding; Hsp90 protein binding