Rabbit anti-Human CGNL1 Polyclonal Antibody | anti-CGNL1 antibody

CGNL1, NT (CGNL1, JACOP, KIAA1749, Cingulin-like protein 1, Junction-associated coiled-coil protein, Paracingulin) (APC)

Cat. Num. AAA6285470

• Gene Names: CGNL1; JACOP; PCING
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CGNL1; Polyclonal Antibody; NT (CGNL1; JACOP; KIAA1749; Cingulin-like protein 1; Junction-associated coiled-coil protein; Paracingulin) (APC); Paracingulin; anti-CGNL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
• Sequence Length: 1302

• Applicable Applications for anti-CGNL1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CGNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-344 amino acids from the N-terminal region of human CGNL1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CGNL1 Antibody (N-term) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the CGNL1 antibody detected the CGNL1 protein (arrow).)

Related Product Information for anti-CGNL1 antibody

CGNL1 may be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (By similarity).

Product Categories/Family for anti-CGNL1 antibody

Antibodies; Connexin; Junction Proteins

References

Guillemot, L., et al. Mol. Biol. Cell 19(10):4442-4453(2008). Ohnishi, H., et al. J. Biol. Chem. 279(44):46014-46022(2004). Shozu, M., et al. N. Engl. J. Med. 348(19):1855-1865(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 31982906
• NCBI GeneID: 84952
• NCBI Accession #: NP_116255.2
• NCBI GenBank Nucleotide #: NP_116255.2
• UniProt Accession #: Q0VF96
• NCBI Official Full Name: cingulin-like protein 1
• NCBI Official Synonym Full Names: cingulin like 1
• NCBI Official Symbol: CGNL1
• NCBI Official Synonym Symbols: JACOP; PCING
• NCBI Protein Information: cingulin-like protein 1
• UniProt Protein Name: Cingulin-like protein 1
• Protein Family: Cingulin-like protein
• UniProt Gene Name: CGNL1
• UniProt Synonym Gene Names: JACOP; KIAA1749
• UniProt Entry Name: CGNL1_HUMAN

NCBI Description

This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]