Rabbit cGMP Polyclonal Antibody | anti-cGMP antibody

cGMP antibody

Cat. Num. AAA535016

• Gene Names: KCNA10; Kcn1; Kv1.8
• Applications: User optimized
• Synonyms: cGMP; Polyclonal Antibody; cGMP antibody; Polyclonal cGMP; Anti-cGMP; Cyclic GMP; anti-cGMP antibody

• Host: Rabbit
• Clonality: Polyclonal
• Form/Format: Supplied as neat serum
• Sequence Length: 511

• Applicable Applications for anti-cGMP antibody: User optimized
• Biological Significance: Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP, most notably by activating intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface.
• Cross-Reactivity: cGMP: 100%
• Immunogen: cGMP antibody was raised in rabbit using cGMP-BSA as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-cGMP antibody

Rabbit polyclonal cGMP antibody

Product Categories/Family for anti-cGMP antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 2138345
• NCBI GeneID: 3744
• UniProt Accession #: Q16322
• Molecular Weight: 57,785 Da
• NCBI Official Full Name: cyclic GMP gated potassium channel
• NCBI Official Synonym Full Names: potassium channel, voltage gated shaker related subfamily A, member 10
• NCBI Official Symbol: KCNA10
• NCBI Official Synonym Symbols: Kcn1; Kv1.8
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 10
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 10
• Protein Family: cGMP-gated cation channel
• UniProt Gene Name: KCNA10
• UniProt Entry Name: KCA10_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

KCNA10: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity; intracellular cyclic nucleotide activated cation channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport