Rabbit anti-Human CGB/hCG-Beta Polyclonal Antibody | anti-CGB1 antibody

CGB/hCG-Beta, ID (CGB, CGB3, Choriogonadotropin subunit beta, Chorionic gonadotrophin chain beta)

Cat. Num. AAA647986

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CGB/hCG-Beta; Polyclonal Antibody; ID (CGB; CGB3; Choriogonadotropin subunit beta; Chorionic gonadotrophin chain beta); Anti -CGB/hCG-Beta; anti-CGB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-CGB1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: CGB/hCG-Beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the Central region of human CGB/hCG-Beta.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CGB/HCG-Beta Antibody (Center) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the CGB/HCG-Beta antibody detected the CGB/HCG-Beta protein (arrow).)

Related Product Information for anti-CGB1 antibody

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.

Product Categories/Family for anti-CGB1 antibody

Antibodies; Abs to Hormones; Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 132566537
• NCBI GeneID: 114335
• NCBI Accession #: NP_203695.2
• NCBI GenBank Nucleotide #: NM_033377.1
• UniProt Accession #: A6NKQ9; A4FVC8; A8MUK6
• Molecular Weight: 20,468 Da
• NCBI Official Full Name: choriogonadotropin subunit beta variant 1
• NCBI Official Synonym Full Names: chorionic gonadotropin, beta polypeptide 1
• NCBI Official Symbol: CGB1
• NCBI Protein Information: choriogonadotropin subunit beta variant 1
• UniProt Protein Name: Choriogonadotropin subunit beta variant 1
• Protein Family: Choriogonadotropin
• UniProt Gene Name: CGB1
• UniProt Entry Name: CGB1_HUMAN

NCBI Description

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

Uniprot Description

Subcellular location: Secreted.

Tissue specificity: Expressed in placenta, testis and pituitary. Ref.1 Ref.5

Sequence similarities: Belongs to the glycoprotein hormones subunit beta family.