Western Blot (WB)
(Western blot analysis CFTR (Phospho-Ser737) using COLO205 whole cell lysates)
Rabbit CFTR Polyclonal Antibody | anti-CFTR antibody
CFTR (Phospho-Ser737) Antibody
Western Blot (WB)
(Western blot analysis CFTR (Phospho-Ser737) using COLO205 whole cell lysates)
Western Blot (WB)
(Western blot analysis CFTR (Phospho-Ser737) using COLO205 whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice
Protein type: Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component: apical plasma membrane; cell surface; cytoplasm; cytosol; early endosome; lysosomal membrane; plasma membrane; protein complex; recycling endosome
Molecular Function: anion transmembrane-transporting ATPase activity; ATP-binding and phosphorylation-dependent chloride channel activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride channel inhibitor activity; chloride channel regulator activity; chloride transmembrane transporter activity; enzyme binding; PDZ domain binding; protein binding
Biological Process: intracellular pH elevation; membrane hyperpolarization; positive regulation of exocytosis; respiratory gaseous exchange; sperm capacitation; transmembrane transport; transport
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary; Vas Deferens, Congenital Bilateral Aplasia Of
Research Articles on CFTR
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Product Notes
The CFTR cftr (Catalog #AAA9416515) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CFTR (Phospho-Ser737) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CFTR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000. Researchers should empirically determine the suitability of the CFTR cftr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CFTR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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