Sheep anti-Human CFHR4 Polyclonal Antibody | anti-CFHR4 antibody

CFHR4 (Complement Factor H-related Protein 4, FHR-4, H Factor-like Protein 4, H-Factor-like 4, H36, CFHL, CFHL4, CFHL4P, CFHR4P, FHR4, HFL4)

Cat. Num. AAA641964

• Gene Names: CFHR4; FHR4; CFHL4; FHR-4
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CFHR4; Polyclonal Antibody; CFHR4 (Complement Factor H-related Protein 4; FHR-4; H Factor-like Protein 4; H-Factor-like 4; H36; CFHL; CFHL4; CFHL4P; CFHR4P; FHR4; HFL4); Anti -CFHR4 (Complement Factor H-related Protein 4; anti-CFHR4 antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CFHR4. Species Crossreactivity: recombinant, human CFHR1, recombinant, human CFHR2 and recombinant, human CFHR5.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with sterile PBS.

• Applicable Applications for anti-CFHR4 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Direct ELISA: 0.5-1ug/ml; Western Blot: 1ug/ml
• Immunogen: Recombinant corresponding to human CFHR4 expressed in Sf21 (AAH74957).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-CFHR4 antibody

CFHR4 (Complement Factor H-related protein 4; also FHR4B) is a 45kD glycoprotein member of the factor H-related protein family. It is synthesized by hepatocytes and circulates in plasma. FHR4(B) binds to C3b and C3d. It also binds to native (pentameric) C-reactive protein (pCRP), and is suggested to promote pCRP binding to necrotic cells surfaces, thus promoting cell clearance. Mature human FHR4B is 312aa in length. It contains five Sushi/SCR domains, the first of which (aa23-85) is associated with pCRP binding. There is a circulating, 86kD alternative splice form termed FHR4A that shows an insertion of 247aa after Asp92. This is considered the dominant isoform, and appears to show the same activity as FHR4B. Over (aa41 -331, human FHR4B shares 61% aa identity with a related molecule found in rat.

Product Categories/Family for anti-CFHR4 antibody

Antibodies; Abs to Complement

NCBI and Uniprot Product Information

• NCBI GI #: 320089550
• NCBI GeneID: 10877
• NCBI Accession #: NP_001188480.1
• NCBI GenBank Nucleotide #: NM_001201551.1
• UniProt Accession #: Q92496; Q9UJY6; A8K9N7; B1ALQ9; C9J7J7
• Molecular Weight: 37,299 Da
• NCBI Official Full Name: complement factor H-related protein 4 isoform 2
• NCBI Official Synonym Full Names: complement factor H-related 4
• NCBI Official Symbol: CFHR4
• NCBI Official Synonym Symbols: FHR4; CFHL4; FHR-4
• NCBI Protein Information: complement factor H-related protein 4
• UniProt Protein Name: Complement factor H-related protein 4
• Protein Family: Complement factor H-related protein
• UniProt Gene Name: CFHR4
• UniProt Synonym Gene Names: CFHL4; FHR4; FHR-4
• UniProt Entry Name: FHR4_HUMAN

NCBI Description

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

CFHR4: Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular region

Molecular Function: lipid transporter activity

Biological Process: lipid transport