Rabbit anti-Human CETP Polyclonal Antibody | anti-CETP antibody

CETP, NT (Lipid Transfer Protein I, Cholesteryl Ester Transfer Protein) (MaxLight 405)

Cat. Num. AAA6468659

• Gene Names: CETP; BPIFF; HDLCQ10
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: CETP; Polyclonal Antibody; NT (Lipid Transfer Protein I; Cholesteryl Ester Transfer Protein) (MaxLight 405); anti-CETP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CETP.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-CETP antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the N-terminal region of human CETP (KLH).
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-CETP Antibody (N-term) in Jurkat cell line lysates (35ug/lane). CETP (arrow) was detected using the purified Pab.)

Western Blot (WB)

(Western blot analysis of CETP (arrow) using rabbit polyclonal CETP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CETP gene.)

Product Categories/Family for anti-CETP antibody

Antibodies; Serum Proteins

References

1. Nagano M., Yamashita S., Hirano K.J. Lipid Res. 43:1011-1018(2002). 2. Morabia A., Cayanis E., Costanza M.C.Hum. Mol. Genet. 12:2733-2743(2003). 3. Liu T., Qian W.-J., Gritsenko M.A.J. Proteome Res. 4:2070-2080(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 169636439
• NCBI GeneID: 1071
• NCBI Accession #: NP_000069
• NCBI GenBank Nucleotide #: NM_000078
• UniProt Accession #: P11597; Q13987; Q13988; Q53YZ1
• Molecular Weight: 47,787 Da
• NCBI Official Full Name: cholesteryl ester transfer protein isoform 1
• NCBI Official Synonym Full Names: cholesteryl ester transfer protein, plasma
• NCBI Official Symbol: CETP
• NCBI Official Synonym Symbols: BPIFF; HDLCQ10
• NCBI Protein Information: cholesteryl ester transfer protein; BPI fold containing family F; lipid transfer protein I
• UniProt Protein Name: Cholesteryl ester transfer protein
• Protein Family: Cholesteryl ester transfer protein
• UniProt Gene Name: CETP
• UniProt Entry Name: CETP_HUMAN

Uniprot Description

CETP: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1). Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding; Vesicle; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: extracellular space; extracellular region; vesicle

Molecular Function: lipid transporter activity; phospholipid transporter activity; cholesterol transporter activity; cholesterol binding; phosphatidylcholine binding; lipid binding; triglyceride binding

Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; cholesterol transport; lipid homeostasis; lipoprotein metabolic process; lipid transport; phosphatidylcholine metabolic process; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; phospholipid transport; triacylglycerol transport; transmembrane transport; phospholipid homeostasis

Disease: Hyperalphalipoproteinemia 1