Rabbit anti-Human, Mouse CERS3 Polyclonal Antibody | anti-CERS3 antibody

CERS3 Antibody

Cat. Num. AAA7108379

• Gene Names: CERS3; ARCI9; LASS3
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G purified
• Synonyms: CERS3; Polyclonal Antibody; CERS3 Antibody; Ceramide synthase 3; CerS3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; LASS3; anti-CERS3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 394

• Applicable Applications for anti-CERS3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:5000
• Immunogen: Recombinant Human Ceramide synthase 3 protein (59-134AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Species: Homo sapiens (Human)
• Research Area: Signal Transduction
• Target Names: CERS3
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: Mouse heart tissueAll lanes: CERS3 antibody at 3.6ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 47 KDaObserved band size: 47 KDa)

Related Product Information for anti-CERS3 antibody

Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.

Product Categories/Family for anti-CERS3 antibody

Cancer; Cell Biology; Metabolism; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 594140617
• NCBI GeneID: 204219
• NCBI Accession #: NP_001277270.1
• NCBI GenBank Nucleotide #: NM_001290341.2
• UniProt Accession #: Q8IU89; Q8NE64; Q8NEN6
• Molecular Weight: 46,316 Da
• NCBI Official Full Name: ceramide synthase 3 isoform 1
• NCBI Official Synonym Full Names: ceramide synthase 3
• NCBI Official Symbol: CERS3
• NCBI Official Synonym Symbols: ARCI9; LASS3
• NCBI Protein Information: ceramide synthase 3
• UniProt Protein Name: Ceramide synthase 3
• Protein Family: Ceramide synthase
• UniProt Gene Name: CERS3
• UniProt Synonym Gene Names: LASS3; CerS3

NCBI Description

This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Uniprot Description

Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.