Rabbit CEP78 Polyclonal Antibody | anti-CEP78 antibody

CEP78 Polyclonal Antibody

Cat. Num. AAA3007573

• Gene Names: CEP78; IP63; CRDHL; C9orf81
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CEP78; Polyclonal Antibody; CEP78 Polyclonal Antibody; Centrosomal protein of 78 kDa; Cep78; C9orf81; anti-CEP78 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CEP78 polyclonal antibody detects endogenous levels of CEP78 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 722

• Applicable Applications for anti-CEP78 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding Human CEP78.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CEP78 polyclonal antibody at 1:500 dilutionLane1:COS-7 whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:CT26 whole cell lysate (40ug) Lane4:H9C2 whole cell lysate (40ug))

Related Product Information for anti-CEP78 antibody

Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene. Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form in a biologically functional way. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is encoded in the genetic code.

NCBI and Uniprot Product Information

• NCBI GI #: 149274621
• NCBI GeneID: 84131
• NCBI Accession #: NP_001092272.1
• NCBI GenBank Nucleotide #: NP_001092272.1
• UniProt Accession #: Q5JTW2
• Molecular Weight: ~ 78kDa
• NCBI Official Full Name: centrosomal protein of 78 kDa isoform a
• NCBI Official Synonym Full Names: centrosomal protein 78
• NCBI Official Symbol: CEP78
• NCBI Official Synonym Symbols: IP63; CRDHL; C9orf81
• NCBI Protein Information: centrosomal protein of 78 kDa
• UniProt Protein Name: Centrosomal protein of 78 kDa
• Protein Family: Centrosomal protein
• UniProt Gene Name: CEP78
• UniProt Synonym Gene Names: C9orf81; Cep78
• UniProt Entry Name: CEP78_HUMAN

NCBI Description

This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients. [provided by RefSeq, Mar 2017]

Uniprot Description

CEP78: Belongs to the CEP78 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 9q21.2

Cellular Component: centrosome; cytosol

Biological Process: organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle