Western Blot (WB)
(Western blot analysis of CENPS expression in SW620 (A), MCF7 (B), A549 (C) whole cell lysates.)
Rabbit anti-Human CENPS Polyclonal Antibody | anti-APITD1 antibody
Anti-CENPS Antibody
Western Blot (WB)
(Western blot analysis of CENPS expression in SW620 (A), MCF7 (B), A549 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of CENPS expression in SW620 (A), MCF7 (B), A549 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]
Uniprot Description
APITD1: DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Belongs to the TAF9 family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: cytosol; nucleoplasm
Molecular Function: chromatin binding; DNA binding; double-stranded DNA binding; protein binding
Biological Process: DNA repair; DNA replication-independent nucleosome assembly at centromere; positive regulation of protein ubiquitination; replication fork processing; resolution of meiotic joint molecules as recombinants; response to DNA damage stimulus; sister chromatid cohesion
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Product Notes
The APITD1 apitd1 (Catalog #AAA8247247) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CENPS Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CENPS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1/500 - 1/2000. Researchers should empirically determine the suitability of the APITD1 apitd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CENPS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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