Western Blot (WB)
(Western blot analysis of CENPN Antibody (C-term) in MCF-7 cell line lysates (35ug/lane).CENPN (arrow) was detected using the purified Pab.)
Rabbit anti-Human CENPN Polyclonal Antibody | anti-CENPN antibody
CENPN Antibody (C-term)
Western Blot (WB)
(Western blot analysis of CENPN Antibody (C-term) in MCF-7 cell line lysates (35ug/lane).CENPN (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CENPN Antibody (C-term) in MCF-7 cell line lysates (35ug/lane).CENPN (arrow) was detected using the purified Pab.)
Flow Cytometry (FC/FACS)
(CENPN Antibody (C-term) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(CENPN Antibody (C-term) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Izuta, H., et al. Genes Cells 11(6):673-684(2006)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
CENPN: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16q23.2
Cellular Component: nucleoplasm; cytosol; nucleus
Biological Process: mitosis; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle; chromosome segregation
Research Articles on CENPN
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Product Notes
The CENPN cenpn (Catalog #AAA9201337) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 311-339. The CENPN Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CENPN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the CENPN cenpn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CENPN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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