Rabbit anti-Human CENPC1 Polyclonal Antibody | anti-CENPC1 antibody

CENPC1, ID (CENPC1, CENPC, ICEN7, Centromere protein C 1, Centromere autoantigen C, Interphase centromere complex protein 7) (PE)

Cat. Num. AAA6285072

• Gene Names: CENPC; MIF2; hcp-4; CENP-C; CENPC1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CENPC1; Polyclonal Antibody; ID (CENPC1; CENPC; ICEN7; Centromere protein C 1; Centromere autoantigen C; Interphase centromere complex protein 7) (PE); Interphase centromere complex protein 7; anti-CENPC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-CENPC1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CENPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 448-475 amino acids from the Central region of human CENPC1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CENPC1 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPC1 antibody detected the CENPC1 protein (arrow).)

Related Product Information for anti-CENPC1 antibody

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq].

Product Categories/Family for anti-CENPC1 antibody

Antibodies; Centromeres

References

Gopalakrishnan, S., et al. Hum. Mol. Genet. 18(17):3178-3193(2009). Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009): Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009). Trazzi, S., et al. PLoS ONE 4 (6), E5832 (2009): Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007).

NCBI and Uniprot Product Information

• NCBI GI #: 68508960
• NCBI GeneID: 1060
• NCBI Accession #: NP_001803.2
• NCBI GenBank Nucleotide #: NM_001812
• UniProt Accession #: Q03188; Q6PIR0; Q8IW27; Q9P0M5
• Molecular Weight: 61,544 Da
• NCBI Official Full Name: Homo sapiens centromere protein C (CENPC), mRNA
• NCBI Official Synonym Full Names: centromere protein C
• NCBI Official Symbol: CENPC
• NCBI Official Synonym Symbols: MIF2; hcp-4; CENP-C; CENPC1
• NCBI Protein Information: centromere protein C; CENP-C 1; centromere autoantigen C; centromere autoantigen C1; centromere protein C 1; interphase centromere complex protein 7
• UniProt Protein Name: Centromere protein C
• UniProt Gene Name: CENPC
• UniProt Synonym Gene Names: CENPC1; ICEN7; CENP-C; CENP-C 1

NCBI Description

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.