Rabbit CELSR3 Polyclonal Antibody | anti-CELSR3 antibody

Rabbit Polyclonal to Human CELSR3

Cat. Num. AAA244968

• Gene Names: CELSR3; FMI1; EGFL1; HFMI1; MEGF2; CDHF11; RESDA1
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CELSR3; Polyclonal Antibody; Rabbit Polyclonal to Human CELSR3; Anti-CELSR3 Antibody (N-Terminus) IHC-plus; Anchor protein; Cadherin family member 11; CDHF11; EGF-like protein 1; EGF-like-domain; multiple 1; Epidermal growth factor-like 1; Flamingo homolog 1; FMI1; KIAA0812; MEGF2; Megf3; HFMI1; Multiple EGF-like domains 2; RESDA1; EGFL1; Human CELSR3; anti-CELSR3 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CELSR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 3312

• Applicable Applications for anti-CELSR3 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (34 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from N-terminal extracellular domain of human CELSR3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset (93%).
• Immunogen Type: Synthetic peptide
• Immunogen: CELSR3 antibody was raised against synthetic 15 amino acid peptide from N-terminal extracellular domain of human CELSR3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset (93%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CELSR3 antibody IHC of human brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CELSR3 antibody

CELSR3 is an Orphan-U GPCR with an unknown ligand.

Product Categories/Family for anti-CELSR3 antibody

Family: GPCR; Subfamily: Orphan-U

NCBI and Uniprot Product Information

• NCBI GI #: 145309304
• NCBI GeneID: 1951
• NCBI Accession #: NP_001398.2
• NCBI GenBank Nucleotide #: NM_001407.2
• UniProt Accession #: Q9NYQ7; O75092
• Molecular Weight: 358,640 Da
• NCBI Official Full Name: cadherin EGF LAG seven-pass G-type receptor 3
• NCBI Official Synonym Full Names: cadherin, EGF LAG seven-pass G-type receptor 3
• NCBI Official Symbol: CELSR3
• NCBI Official Synonym Symbols: FMI1; EGFL1; HFMI1; MEGF2; CDHF11; RESDA1
• NCBI Protein Information: cadherin EGF LAG seven-pass G-type receptor 3; anchor protein; EGF-like protein 1; flamingo homolog 1; cadherin family member 11; EGF-like-domain, multiple 1; multiple EGF-like domains protein 2; epidermal growth factor-like protein 1; multiple epidermal growth factor-like domains protein 2; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
• UniProt Protein Name: Cadherin EGF LAG seven-pass G-type receptor 3
• Protein Family: Cadherin EGF LAG seven-pass G-type receptor
• UniProt Gene Name: CELSR3
• UniProt Synonym Gene Names: CDHF11; EGFL1; FMI1; KIAA0812; MEGF2; EGF-like protein 1; hFmi1; Multiple EGF-like domains protein 2
• UniProt Entry Name: CELR3_HUMAN

NCBI Description

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

Uniprot Description

CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; protein binding; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; axonal fasciculation; neuron migration; cilium biogenesis; homophilic cell adhesion