Rabbit CELSR2 Polyclonal Antibody | anti-CELSR2 antibody

CELSR2 Polyclonal Antibody

Cat. Num. AAA2517534

• Gene Names: CELSR2; EGFL2; MEGF3; CDHF10; Flamingo1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CELSR2; Polyclonal Antibody; CELSR2 Polyclonal Antibody; EGFL2; MEGF3; CDHF10; Flamingo1; anti-CELSR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.8mg/mL (varies by lot)
• Sequence Length: 2923

• Applicable Applications for anti-CELSR2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human CELSR2
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using CELSR2 Polyclonal Antibody at dilution 1:50)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using CELSR2 Polyclonal Antibody at dilution 1:50)

Related Product Information for anti-CELSR2 antibody

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 22095550
• NCBI GeneID: 1952
• Molecular Weight: 317,453 Da
• NCBI Official Full Name: Cadherin EGF LAG seven-pass G-type receptor 2
• NCBI Official Synonym Full Names: cadherin, EGF LAG seven-pass G-type receptor 2
• NCBI Official Symbol: CELSR2
• NCBI Official Synonym Symbols: EGFL2; MEGF3; CDHF10; Flamingo1
• NCBI Protein Information: cadherin EGF LAG seven-pass G-type receptor 2; EGF-like protein 2; EGF-like-domain, multiple 2; cadherin family member 10; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); epidermal growth factor-like 2; epidermal growth factor-like protein 2; flamingo homolog 3; multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; multiple epidermal growth factor-like domains protein 3
• UniProt Protein Name: Cadherin EGF LAG seven-pass G-type receptor 2
• Protein Family: Cadherin EGF LAG seven-pass G-type receptor
• UniProt Gene Name: CELSR2
• UniProt Synonym Gene Names: CDHF10; EGFL2; KIAA0279; MEGF3; EGF-like protein 2; Multiple EGF-like domains protein 3
• UniProt Entry Name: CELR2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

CELSR2: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Protein type: Membrane protein, multi-pass; Cell development/differentiation; Receptor, GPCR; Membrane protein, integral; GPCR, family 2

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cerebrospinal fluid secretion; regulation of protein localization; Wnt receptor signaling pathway; regulation of cell-cell adhesion; regulation of transcription, DNA-dependent; ventricular system development; neural plate anterioposterior pattern formation; dendrite morphogenesis; neuron migration; cilium biogenesis; homophilic cell adhesion